ArticleNPJ biofilms and microbiomes2023
Survey of the infant male urobiome and genomic analysis of Actinotignum spp.
Article in NPJ biofilms and microbiomes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 13 citations in OpenAlex.
- Whole-genome sequence analyses reveal cryptic species-level diversity among clinicalMicrobiology spectrum · 2026Article
- Urinary biochemical ecology reveals microbiome-metabolite interactions and metabolic markers of recurrent urinary tract infection.NPJ biofilms and microbiomes · 2025Article
- Emerging Technologies for the Diagnosis of Urinary Tract Infections: Advances in Molecular Detection and Resistance Profiling.Diagnostics (Basel, Switzerland) · 2025Review
- The urinary microbiome: the next frontier of bacterial ecology.Journal of bacteriology · 2025Review
- Exploring Childhood Lower Urinary Tract Symptoms (LUTS), Urinary Tract Infections (UTIs) and the Microbiome-A Systematic Review.Life (Basel, Switzerland) · 2025Review
- Rapid and accurate testing for urinary tract infection: new clothes for the emperor.Clinical microbiology reviews · 2025Review
- Novel technologies for the diagnosis of urinary tract infections.Journal of clinical microbiology · 2025Review
- Urinary Microbiota of Healthy Prepubescent Girls and Boys-A Pilot Study.Children (Basel, Switzerland) · 2024Article
- Urinary Tract Infection in Children: An Up-To-Date Study.Biomedicines · 2024Review
- Synthesis of current pediatric urinary microbiome research.Frontiers in pediatrics · 2024Review
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
Abstract
The urinary bladder harbors a community of microbes termed the urobiome, which remains understudied. In this study, we present the urobiome of healthy infant males from samples collected by transurethral catheterization. Using a combination of enhanced culture and amplicon sequencing, we identify several common bacterial genera that can be further investigated for their effects on urinary health across the lifespan. Many genera were shared between all samples suggesting a consistent urobiome composition among this cohort. We note that, for this cohort, early life exposures including mode of birth (vaginal vs. Cesarean section), or prior antibiotic exposure did not influence urobiome composition. In addition, we report the isolation of culturable bacteria from the bladders of these infant males, including Actinotignum spp., a bacterial genus that has been associated with urinary tract infections in older male adults. Herein, we isolate and sequence 9 distinct strains of Actinotignum spp. enhancing the genomic knowledge surrounding this genus and opening avenues for delineating the microbiology of this urobiome constituent. Furthermore, we present a framework for using the combination of culture-dependent and sequencing methodologies for uncovering mechanisms in the urobiome.
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