Evidence map›Paper›PMID 38040569›Full record

Trial reportThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2024

Efficacy of the Transdiagnostic Intervention for Sleep and Circadian Dysfunction for Depression Symptoms and Sleep-Wake Disruption in Older and Younger Adults: Secondary Age-Stratified Analysis of a Randomized Controlled Trial.

Stephen F Smagula, Caitlin E Gasperetti, Daniel J Buysse, Michael R Irwin, Robert T Krafty, Sarah E Lim, Charles F Reynolds, William V McCall, Allison G Harvey

Open access · greenAbstract readRandomized Controlled TrialPragmatic Clinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Stephen F SmagulaDepartment of Psychiatry (SFS, DJB, SEL, CFR), School of Medicine, University of Pittsburgh, Pittsburgh, PA. Electronic address: sfs26@pitt.edu.
Caitlin E GasperettiDepartment of Child and Adolescent Psychiatry (CEG), Hassenfeld Children's Hospital at NYU Langone, New York, NY.
Daniel J BuysseDepartment of Psychiatry (SFS, DJB, SEL, CFR), School of Medicine, University of Pittsburgh, Pittsburgh, PA.
Michael R IrwinNorman Cousins Center for Psychoneuroimmunology (MRI), Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA; Department of Psychiatry and Biobehavioral Sciences (MRI), University of California, Los Angeles, Los Angeles, CA.
Robert T KraftyDepartment of Biostatistics and Bioinformatics (RTK), Rollins School of Public Health, Emory University, Atlanta, GA.
Sarah E LimDepartment of Psychiatry (SFS, DJB, SEL, CFR), School of Medicine, University of Pittsburgh, Pittsburgh, PA.
Charles F ReynoldsDepartment of Psychiatry (SFS, DJB, SEL, CFR), School of Medicine, University of Pittsburgh, Pittsburgh, PA.
William V McCallDepartment of Psychiatry and Health Behavior (WVMC), Medical College of Georgia, Augusta, GA.
Allison G HarveyDepartment of Psychology (AGH), University of California, Berkeley, CA.
University of Pittsburgh · USAugusta University · USEmory University · USUniversity of California, Berkeley · USUniversity of California, Los Angeles · US

Funding

Implementing and Sustaining a Transdiagnostic Sleep and Circadian Treatment to Improve Severe Mental Illness Outcomes in Community Mental Health.R01MH120147 · NIMH · UNIVERSITY OF CALIFORNIA BERKELEY · PI HARVEY, ALLISON G · 2019 to 2023
$3.9M
A transdiagnostic sleep and circadian treatment to improve community SMI outcomesR01MH105513 · NIMH · UNIVERSITY OF CALIFORNIA BERKELEY · PI HARVEY, ALLISON G · 2015 to 2018
$2.8M
Improving sleep and circadian functioning, daytime functioning, and well-being for midlife and older adults by improving patient memory for a transdiagnostic sleep and circadian treatmentR01AG082651 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI Allison G Harvey · 2023 to 2026
$2.5M
Sleep-wake, cognitive, and affective risks for a worse course of post-discharge suicidal ideation in older adults with major depressionR21MH120511 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SMAGULA, STEPHEN F · 2020 to 2020
$430k
NIA NIH HHS R01 AG082651NIMH NIH HHS R01 MH105513NIMH NIH HHS R01 MH120147NIMH NIH HHS R21 MH120511
6 · The paper itself

Abstract

objectivePerform a secondary analysis examining the efficacy of the Transdiagnostic Intervention for Sleep and Circadian Dysfunction (TranS-C) for depression symptom responses, and explore changes in potential target mechanisms.

designSecondary analysis of a randomized controlled trial with convenience age subsamples (younger (20-49 year; n = 52) versus and older (50-71 years; n = 35)).

settingCommunity mental health clinics.

participantsEighty-seven adults with serious mental illness.

interventionTranS-C versus treatment as usual (TAU). MEASUREMENTS: Outcomes were depression symptoms (Quick Inventory of Depression Symptoms), insomnia symptoms (Insomnia Severity Index), and objective sleep-wake rhythm measures (interdaily stability and relative amplitude).

resultsDepression response rates (≥50% symptom reductions) were higher in the TranS-C (35.0%) than the TAU (8.8%) group 6-months postintervention (χ

conclusionConfirmatory trials are needed, given the low age-specific sample sizes here, to determine if TranS -C's produces durable depression responses by increasing sleep-wake rhythm stability in older adults and improving insomnia symptoms in younger adults. BRIEF ARTICLE SUMMARY: The authors evaluated preliminary efficacy of a behavioral intervention that targets sleep/sleep-wake rhythms, the Transdiagnostic Intervention for Sleep and Circadian Dysfunction (TranS-C), for depression symptoms in people with serious mental illness. TranS-C was associated with higher depression response rates than treatment as usual 6-months postintervention. The degree of depression symptom response 6-months later was related to the degree of treatment phase improvements in interdaily stability (in older adults) and reduction in insomnia severity (in younger adults). A pragmatic nonpharmacologic intervention, the Transdiagnostic Intervention for Sleep and Circadian Dysfunction, has preliminary efficacy for improving sleep-wake factors and depression symptoms.

Indexed as

Sleep Initiation and Maintenance DisordersAgedDepressionHumansSleepTreatment Outcomebehavioral interventiondepressionrest-activity rhythmSleepsleep-wakesuicidal ideation

Identifiers

PMID38040569
PMCPMC10950538
OpenAlexW4388599305

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.