Evidence map›Paper›PMID 38040543›Full record

ArticleHuman immunology2024

Single-cell transcriptomics of peripheral blood mononuclear cells indicates impaired immune and inflammatory responses in alcohol-associated hepatitis.

Xiaochen Liu, Zhang-Xu Liu, Timothy R Morgan, Trina M Norden-Krichmar

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Xiaochen LiuDepartment of Epidemiology and Biostatistics, University of California, Irvine, CA, USA.
Zhang-Xu LiuDivision of Gastrointestinal and Liver Diseases, Department of Medicine, University of Southern California, Los Angeles, CA, USA.
Timothy R MorganMedicine and Research Services, VA Long Beach Healthcare System, Long Beach, CA, USA; Department of Medicine, University of California, Irvine, CA, USA.
Trina M Norden-KrichmarDepartment of Epidemiology and Biostatistics, University of California, Irvine, CA, USA. Electronic address: tnordenk@uci.edu.
University of California, Irvine · USUniversity of Southern California · US

Funding

Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Christine Hui · 1994 to 2026
$57.9M
A prospective, randomized, clinical trial to evaluate two novel therapies, mycophU01AA021886 · NIAAA · SOUTHERN CALIFORNIA INST FOR RES/EDUC · PI MORGAN, TIMOTHY ROSS · 2013 to 2017
$3.1M
Immunity in alcoholic hepatitis.U01AA021857 · NIAAA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI LIU, ZHANGXU · 2013 to 2017
$1.5M
Transcriptomics of Liver in Alcoholic HepatitisU01AA021838 · NIAAA · UNIVERSITY OF CALIFORNIA-IRVINE · PI NORDEN-KRICHMAR, TRINA · 2013 to 2017
$1.3M
High-Throughput DNA SequencerS10OD021718 · OD · UNIVERSITY OF CALIFORNIA-IRVINE · PI SANDMEYER, SUZANNE · 2016 to 2016
$600k
PacBio RS Single Molecule, Real-Time (SMRT) DNA SequencerS10OD010794 · OD · UNIVERSITY OF CALIFORNIA-IRVINE · PI SANDMEYER, SUZANNE · 2012 to 2012
$600k
High Throughput DNA SequencerS10RR025496 · NCRR · UNIVERSITY OF CALIFORNIA-IRVINE · PI SANDMEYER, SUZANNE · 2009 to 2009
$500k
Southern California Alcoholic Hepatitis Consortium Administrative CoreU01AA021884 · NIAAA · SOUTHERN CALIFORNIA INST FOR RES/EDUC · PI MORGAN, TIMOTHY ROSS · 2013 to 2016
$118k
NCI NIH HHS P30 CA062203NCRR NIH HHS S10 RR025496NIAAA NIH HHS U01 AA021838NIAAA NIH HHS U01 AA021857NIAAA NIH HHS U01 AA021884NIAAA NIH HHS U01 AA021886NIH HHS S10 OD010794NIH HHS S10 OD021718
6 · The paper itself

Abstract

Alcohol-associated hepatitis (AH) is often diagnosed at advanced stages, and severe AH usually carries poor prognosis and high short-term mortality. In addition, it is challenging to understand the molecular mechanisms of immune dysregulation and inflammation in AH due to the cellular complexity and heterogeneity. Using single-cell RNA sequencing, previous studies found that AH causes dysfunctional innate immune response in monocytes, involving activation of pattern recognition receptors (PRRs) and cytokine signaling pathways. To better understand the coordinated systemic immune response in AH patients, we performed combined single-cell transcriptome, cell-surface protein, and lymphocyte antigen receptor analysis of peripheral blood mononuclear cell (PBMC) samples. Our results showed inflammatory cytokines and chemokines were highly expressed in AH, including IL-2, IL-32, CXC3R1 and CXCL16 in monocytes and NK cells, whereas HLA-DR genes were reduced in monocytes. In addition, we also found altered differentiation of T-helper cells (T

Indexed as

Hepatitis, AlcoholicLeukocytes, MononuclearChemokinesCytokinesGene Expression ProfilingHumansNK Cell Lectin-Like Receptor Subfamily CChemokinesCytokinesKLRC2 protein, humanNK Cell Lectin-Like Receptor Subfamily CAlcohol-associated hepatitisImmune responseInflammatory cytokinesPBMCSingle-cell RNA-seq

Identifiers

PMID38040543
PMCPMC12549007
OpenAlexW4389160352

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.