Evidence map›Paper›PMID 38039560›Full record

ArticleJournal of inorganic biochemistry2024

Forming a chromium-based interstrand DNA crosslink: Implications for carcinogenicity.

Silas Brown, Sydney Marchi, C Sumner Thomas, Ashlyn R Hale, Molly Lockart, Michael K Bowman, George Christou, Stephen A Woski, John B Vincent

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of inorganic biochemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Do Ternary DNA-Cr(III)-Small Molecule Adducts Form?Biological trace element research · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Silas BrownDepartment of Chemistry and Biochemistry, The University of Alabama, Tuscaloosa, AL 35487-0336, USA.
Sydney MarchiDepartment of Chemistry and Biochemistry, The University of Alabama, Tuscaloosa, AL 35487-0336, USA.
C Sumner ThomasDepartment of Chemistry and Biochemistry, The University of Alabama, Tuscaloosa, AL 35487-0336, USA.
Ashlyn R HaleDepartment of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA.
Molly LockartDepartment of Chemistry and Biochemistry, The University of Alabama, Tuscaloosa, AL 35487-0336, USA; Department of Chemistry and Biochemistry, Samford University, Birmingham, AL 35229, USA.
Michael K BowmanDepartment of Chemistry and Biochemistry, The University of Alabama, Tuscaloosa, AL 35487-0336, USA.
George ChristouDepartment of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA.
Stephen A WoskiDepartment of Chemistry and Biochemistry, The University of Alabama, Tuscaloosa, AL 35487-0336, USA.
John B VincentDepartment of Chemistry and Biochemistry, The University of Alabama, Tuscaloosa, AL 35487-0336, USA. Electronic address: jvincent@ua.edu.

Funding

Molecular Structure of Chromium-DNA AdductsR15ES033800 · NIEHS · UNIVERSITY OF ALABAMA IN TUSCALOOSA · PI VINCENT, JOHN BERTRAM, WISE, JOHN PIERCE · 2022 to 2022
$434k
NIEHS NIH HHS R15 ES033800
6 · The paper itself

Abstract

The reduction of the carcinogen chromate has been proposed to lead to three Cr(III)-containing DNA lesions: binary adducts (Cr(III) and DNA), interstrand crosslinks, and ternary adducts (Cr(III) linking DNA to a small molecule or protein). Although the structures of binary adducts have recently been elucidated, the structures of interstrand crosslinks and ternary adducts are not known. Analysis of Cr(III) binding to an oligonucleotide duplex containing a 5'-CG site allows elucidation of the structure of an oxide- or hydroxide-bridged binuclear Cr(III) assembly bridging the two strands of DNA. One Cr(III) is directly coordinated by the N-7 atom of a guanine residue, and the complex straddles the helix to form a hydrogen bond between another guanine residue and a Cr(III)-bound aquo ligand. No involvement of the phosphate backbone was observed. The properties and stability of this Cr-O(H)-Cr-bridged complex differ significantly from those reported for Cr-induced interstrand crosslinks, suggesting that interstrand crosslinks resulting from chromate reduction may be organic in nature.

Indexed as

ChromatesChromiumDNADNA AdductsDNA DamageGuanineChromatesChromiumDNADNA AdductsGuanineBinary adductChromateChromiumDNAInterstrand crosslink

Identifiers

PMID38039560
PMCPMC10872647

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.