SynthesisPloS one2023
Impact of depression on stroke outcomes among stroke survivors: Systematic review and meta-analysis.
Synthesis in PloS one, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Prevalence of mental disorders among people with neurologic conditions in Nigeria: a systematic review.BMC psychiatry · 2025Pooled it
- Effects of noninvasive brain stimulation in the treatment of poststroke depression: an overview of systematic reviews.Frontiers in neurologyPooled it
- Functional Independence and Self-Reported Depressive Symptoms 6-24 Months After Stroke: A Multicentre Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2026Article
- Changes in Frailty, Depression, and Loneliness among Stroke Survivors and Their Spouses.Cerebrovascular diseases (Basel, Switzerland) · 2026Article
- Post-stroke depression management in the Israeli primary care setting: a retrospective cohort study.BMJ open · 2026Article
- Long-Term Outcome After Intensive Stroke Rehabilitation.Journal of clinical medicine · 2026Article
- Poststroke anxiety and depression: epidemiology, mechanisms, and management strategies.Frontiers in psychiatry · 2026Review
- Prevalence and factors associated with post-stroke depression: a cross-sectional analysis of a prospectively assembled cohort in Eastern Saudi Arabia.Frontiers in neurology · 2026Article
- Drug-related problems and their determinants among stroke patients in suburban China: a PCNE-based analysis with targeted initiatives.Frontiers in public health · 2026Article
- Machine learning combined with resting-state functional MRI to characterize functional brain differences in post-stroke depression.Frontiers in psychiatry · 2026Article
- Comorbid depression is associated with non-routine discharge following treatment of unruptured cerebral aneurysms.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia · 2025Article
- Cognitive Impairment and Psychological Morbidity Among Stroke Survivors in Rehabilitation: A Cross-Sectional Analysis.Journal of clinical medicine · 2025Article
- Factors associated with depressive symptoms among stroke survivors in public hospitals of Amhara regional State, Ethiopia: a multicenter cross-sectional study.Scientific reports · 2025Article
- Sleep mediates the association between stroke and all cause mortality in the NHANES cohort.Scientific reports · 2025Article
- Long-term outcomes of depression up to 10-years after stroke in the South London Stroke Register: a population-based study.The Lancet regional health. Europe · 2025Article
- The effect of motivational interviewing on patients with early post-stroke depression: a quasi-experimental study.BMC psychiatry · 2025Article
- Association of Life's Crucial 9 with all-cause and cardiovascular mortality in stroke survivors and predictive value for mortality compared with Life's Essential 8: evidence from NHANES 2005-2018.Frontiers in neurology · 2025Article
- Rate of Post-Stroke Depression and Associated Factors in Saudi Single Tertiary Medical Center.Journal of multidisciplinary healthcare · 2025Article
- Existential concerns, community integration and psychological depression among female stroke survivors in Nigeria.Frontiers in stroke · 2025Article
- Development and validation of a dynamic nomogram for high care dependency during the hospital-family transition periods in older stroke patients.BMC geriatrics · 2024Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundDepression may negatively affect stroke outcomes and the progress of recovery. However, there is a lack of updated comprehensive evidence to inform clinical practice and directions of future studies. In this review, we report the multidimensional impact of depression on stroke outcomes.
methodsData sources. PubMed, PsycINFO, EMBASE, and Global Index Medicus were searched from the date of inception. Eligibility criteria. Prospective studies which investigated the impact of depression on stroke outcomes (cognition, returning to work, quality of life, functioning, and survival) were included. Data extraction. Two authors extracted data independently and solved the difference with a third reviewer using an extraction tool developed prior. The extraction tool included sample size, measurement, duration of follow-up, stroke outcomes, statistical analysis, and predictors outcomes. Risk of bias. We used Effective Public Health Practice Project (EPHPP) to assess the quality of the included studies.
resultsEighty prospective studies were included in the review. These studies investigated the impact of depression on the ability to return to work (n = 4), quality of life (n = 12), cognitive impairment (n = 5), functioning (n = 43), and mortality (n = 24) where a study may report on more than one outcome. Though there were inconsistencies, the evidence reported that depression had negative consequences on returning to work, functioning, quality of life, and mortality rate. However, the impact on cognition was not conclusive. In the meta-analysis, depression was associated with premature mortality (HR: 1.61 (95% CI; 1.33, 1.96)), and worse functioning (OR: 1.64 (95% CI; 1.36, 1.99)).
conclusionDepression affects many aspects of stroke outcomes including survival The evidence is not conclusive on cognition and there was a lack of evidence in low-income settings. The results showed the need for early diagnosis and intervention of depression after stroke. The protocol was pre-registered on the International Prospective Register of Systematic Review (PROSPERO) (CRD42021230579).
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Registered trials
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