ArticleCell reports2023
Leptin signaling in the dorsomedial hypothalamus couples breathing and metabolism in obesity.
Open access · goldAbstract read
In one paragraph
Article in Cell reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 14 citations in OpenAlex.
- Brain-Wide Connectivity and Topographic Organization of Leptin Receptor Neurons in the Dorsomedial Hypothalamus.CNS neuroscience & therapeutics · 2026Article
- Circuit Mechanisms Underlying the Contribution of Leptin Receptor-Expressing Neurons in the Nucleus Tractus Solitarius to Ventilatory Homeostasis.Neuroscience bulletin · 2026Article
- GLP-1 Receptor Agonists in Obstructive Sleep Apnea: A Translational Perspective on Mechanisms and Clinical Implications.International journal of molecular sciences · 2026Review
- Leptin alleviates obesity hypoventilationbioRxiv : the preprint server for biology · 2026Article
- Glucagon-like Peptide-1 and Dual GIP/GLP-1 Receptor Agonists in Brain: Exploring the Expanding Role and Safety in Neuropsychiatry.International journal of molecular sciences · 2026Review
- Early-Onset Monogenic Obesity due to Leptin Receptor Deficiency: Fatal Outcome in Childhood in the Era of Precision Therapy.Hormone research in paediatrics · 2026Article
- Melanocortin receptor 4 agonist setmelanotide treats opioid-induced respiratory depression.bioRxiv : the preprint server for biology · 2026Article
- Endotypic traits and lung function in patients with obstructive sleep apnea comorbid with obesity hypoventilation syndrome.Sleep & breathing = Schlaf & Atmung · 2026Article
- The pathogenic theory of homeostasis threshold deviation (HTD) in wide-range oscillatory physiological parameters: novel perspectives for hypertension and metabolic disease treatment.Life metabolism · 2025Review
- Melanocortin Signaling in the Carotid Body as a Putative Cause of Hypertension.Circulation research · 2025Article
- Detection of central and obstructive sleep apneas in mice: A new surgical and recording protocol.PloS one · 2025Article
- Hypothalamic Regulation of Cardiorespiratory Functions: Insights into the Dorsomedial and Perifornical Pathways.Biology · 2024Review
- Revisiting the Role of Serotonin in Sleep-Disordered Breathing.International journal of molecular sciences · 2024Review
- Chemogenetic activation of the diaphragm after spinal cord injury in rats.Respiratory physiology & neurobiologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 3 institutions in 2 countries.
Mateus R AmorimDepartment of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA; Department of Anesthesiology and Critical Care Medicine, George Washington University, Washington, DC 20037, USA. Electronic address: amorimmr@hotmail.com.
Xin WangDepartment of Pharmacology and Physiology, George Washington University, Washington, DC 20037, USA.
O AungDepartment of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA.
Shannon Bevans-FontiDepartment of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA; Department of Anesthesiology and Critical Care Medicine, George Washington University, Washington, DC 20037, USA.
Frederick Anokye-DansoDepartment of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA.
Caitlin RibeiroDepartment of Pharmacology and Physiology, George Washington University, Washington, DC 20037, USA.
Joan EscobarDepartment of Pharmacology and Physiology, George Washington University, Washington, DC 20037, USA.
Carla FreireDepartment of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA.
Huy PhoDepartment of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA.
Olga DergachevaDepartment of Pharmacology and Physiology, George Washington University, Washington, DC 20037, USA.
Luiz G S BrancoUniversity of São Paulo, Ribeirão Preto, São Paulo 14040-904, Brazil.
Rexford S AhimaDepartment of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA.
David MendelowitzDepartment of Pharmacology and Physiology, George Washington University, Washington, DC 20037, USA.
Vsevolod Y PolotskyDepartment of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA; Department of Anesthesiology and Critical Care Medicine, George Washington University, Washington, DC 20037, USA; Department of Pharmacology and Physiology, George Washington University, Washington, DC 20037, USA. Electronic address: vsevolod.polotsky@gwu.edu.
George Washington University · USJohns Hopkins University · USUniversidade de São Paulo · BR
Funding
Melanocortin 4 signaling in the carotid body in obesityR01HL133100 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Vsevolod Y Polotsky, Wan-yee Tang · 2016 to 2026
$7.1MTreatment of Sleep Apnea by Targeting Leptin SignalingR01HL128970 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI MENDELOWITZ, DAVID, POLOTSKY, VSEVOLOD Y · 2015 to 2023
$5.4MChemogenetic approach to treat Obstructive Sleep ApneaR01HL138932 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI POLOTSKY, VSEVOLOD Y · 2017 to 2020
$2.4MZeiss 980 confocal microscope with 32-channel spectral detector, Airy Scan, and Chameleon Discovery IR laser for 2-photon excitationS10OD032420 · OD · GEORGE WASHINGTON UNIVERSITY · PI POPRATILOFF, ANASTAS · 2022 to 2022
$947kNHLBI NIH HHS R01 HL128970NHLBI NIH HHS R01 HL133100NHLBI NIH HHS R01 HL138932NIH HHS S10 OD032420
Abstract
Mismatch between CO
Indexed as
HypoventilationLeptinAnimalsHypothalamusMiceObesityReceptors, LeptinRespirationLeptinReceptors, LeptinCP: MetabolismCP: Neurosciencedesigner receptor exclusively activated by designer drugsdorsal raphe nucleushypercapnic ventilatory responseinspiratory flow limitationintranasal administrationleptin receptorobesity hypoventilationobstructive sleep apneaserotoninsleep disordered breathing
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.