Evidence map›Paper›PMID 38038730›Full record

ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2024

Analysis of the ocular surface functional unit in episodic migraine.

Ágnes Patzkó, Adrienne Csutak, Noémi Tóth, Zsófia Kölkedi, Zoltán Pfund, Gréta Kis-Jakab, Edit Bosnyák, Renáta Rozgonyi, Eszter Szalai

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 2 pooled it
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 syntheses or guidelines pooled it, 3 citations in OpenAlex.

  1. Corneal nerve alterations in migraine: a systematic review of in vivo confocal microscopy and esthesiometry findings.Contact lens & anterior eye : the journal of the British Contact Lens Association · 2026
    Pooled it
  2. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Ágnes PatzkóDepartment of Ophthalmology, University of Pécs Medical School, Rákóczi u. 2, 7623, Pécs, Hungary.
Adrienne CsutakDepartment of Ophthalmology, University of Pécs Medical School, Rákóczi u. 2, 7623, Pécs, Hungary.
Noémi TóthDepartment of Ophthalmology, University of Pécs Medical School, Rákóczi u. 2, 7623, Pécs, Hungary.
Zsófia KölkediDepartment of Ophthalmology, University of Pécs Medical School, Rákóczi u. 2, 7623, Pécs, Hungary.
Zoltán PfundDepartment of Neurology, University of Pécs Medical School, Rét u. 2, 7623, Pécs, Hungary.
Gréta Kis-JakabDepartment of Neurology, University of Pécs Medical School, Rét u. 2, 7623, Pécs, Hungary.
Edit BosnyákDepartment of Neurology, University of Pécs Medical School, Rét u. 2, 7623, Pécs, Hungary.
Renáta RozgonyiDepartment of Neurology, University of Pécs Medical School, Rét u. 2, 7623, Pécs, Hungary.
Eszter SzalaiDepartment of Ophthalmology, University of Pécs Medical School, Rákóczi u. 2, 7623, Pécs, Hungary. szalai.eszter@pte.hu.ORCID http://orcid.org/0000-0002-6723-0914
University of Pecs · HU

Funding

National Research, Development and Innovation Office ÚNKP-23-5
6 · The paper itself

Abstract

aimMigraine is a chronic neurovascular disease that affects the trigeminovascular system. The purpose of this study was to evaluate corneal subbasal nerve fibers, dendritic cells and to measure tear film parameters in migraine. PATIENTS AND

methods87 eyes of 44 patients suffering from migraine with a mean age of 33.23 ± 11.41 years were included in our study. 25 age-matched controls (mean age of 30.16 ± 12.59 years; P = 0.162) were recruited. The corneal subbasal plexus and the dendritic cells (DC) were analyzed using in vivo confocal microscopy (Heidelberg Retina Tomograph II Rostock Cornea Module; Heidelberg Engineering GmbH), and the tear film was imaged using LacryDiag (Quantel Medical, France).

resultsRegarding the subbasal nerve fibers of the cornea, none of the examined parameters differed significantly in migraine patients from controls. We found a significant increase in the corneal DC density (P < 0.0001) and DC area (P < 0.0001) in migraine patients compared to healthy volunteers. DC density showed a positive correlation with the monthly attack frequency (r = 0.32, P = 0.041) and the DC area a negative correlation with corneal nerve branch density (r = -0.233, P = 0.039), nerve fiber length (r = -0.232, P = 0.04) and total branch density (r = -0.233, P = 0.039). Using LacryDiag a significant loss of Meibomian gland area could be detected on the superior eyelid (P = 0.005) in migraine.

conclusionsOur results suggest the presence of neuroinflammation in the cornea of migraine patients affecting the peripheral trigeminal system. Dendritic cells surrounding the subbasal plexus may be involved in the activation and modulation of pain in migraine.

Indexed as

CorneaMigraine DisordersAdolescentAdultHumansMicroscopy, ConfocalNerve FibersOphthalmic NerveRetinaYoung AdultCorneaCorneal nervesDendritic cellIn vivo corneal confocal microscopyMigraine

Identifiers

PMID38038730
PMCPMC11031433
OpenAlexW4389225882

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.