Evidence map›Paper›PMID 38038715›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2024

Arterial stiffness mediates the association between age and processing speed at low levels of microvascular function in humans across the adult lifespan.

Kyndall V Ransom, Miranda K Traylor, Genevieve B Batman, Madhuri S Mulekar, Benjamin D Hill, Amy R Nelson, Joshua L Keller

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. A peripheral perspective on brain health: vascular and skeletal muscle contributions.American journal of physiology. Heart and circulatory physiology · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. The interaction between dysfunction of vasculature and tauopathy in Alzheimer's disease and related dementias.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Kyndall V RansomIntegrative Laboratory of Exercise and Applied Physiology, Department of Health, Kinesiology, and Sport, College of Education and Professional Studies, University of South Alabama, Mobile, Alabama, United States.ORCID 0009-0005-9030-4087
Miranda K TraylorIntegrative Laboratory of Exercise and Applied Physiology, Department of Health, Kinesiology, and Sport, College of Education and Professional Studies, University of South Alabama, Mobile, Alabama, United States.ORCID 0000-0003-2962-3597
Genevieve B BatmanIntegrative Laboratory of Exercise and Applied Physiology, Department of Health, Kinesiology, and Sport, College of Education and Professional Studies, University of South Alabama, Mobile, Alabama, United States.
Madhuri S MulekarDepartment of Mathematics and Statistics, College of Arts and Sciences, University of South Alabama, Mobile, Alabama, United States.
Benjamin D HillPsychology Department, College of Arts and Sciences, University of South Alabama, Mobile, Alabama, United States.ORCID 0000-0002-5797-5082
Amy R NelsonDepartment of Physiology and Cell Biology, College of Medicine, University of South Alabama, Mobile, Alabama, United States.
Joshua L KellerIntegrative Laboratory of Exercise and Applied Physiology, Department of Health, Kinesiology, and Sport, College of Education and Professional Studies, University of South Alabama, Mobile, Alabama, United States.ORCID 0000-0003-0756-9358
University of South Alabama · US

Funding

UAB Center for Clinical and Translational Science (CCTS)UL1TR001417 · NCATS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KIMBERLY, ROBERT P. · 2015 to 2018
$31.4M
HHS | NIH | National Center for Advancing Translational Sciences (NCATS) UL1TR001417NCATS NIH HHS UL1 TR001417
6 · The paper itself

Abstract

The function of micro- and macrovessels within the peripheral vasculature has been identified as a target for the investigation of potential cardiovascular-based promoters of cognitive decline. However, little remains known regarding the interaction of the micro- and macrovasculature as it relates to cognitive function, especially in cognitively healthy individuals. Therefore, our purpose was to unravel peripheral factors that contribute to the association between age and processing speed. Ninety-nine individuals (51 men, 48 women) across the adult life span (19-81 yr) were used for analysis. Arterial stiffness was quantified as carotid-femoral pulse-wave velocity (cfPWV) and near-infrared spectroscopy assessed maximal tissue oxygenation (Sto

Indexed as

LongevityVascular StiffnessAdultBlood PressureFemaleHumansIschemiaMaleProcessing SpeedPulse Wave Analysiscognitionnear-infrared spectroscopyperipheral vascular functionpulse pressurepulse wave velocity

Identifiers

PMID38038715
PMCPMC11219056
OpenAlexW4389222011

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.