Evidence map›Paper›PMID 38038709›Full record

ArticleACS nano2023

Cyclophospholipids Enable a Protocellular Life Cycle.

Ö Duhan Toparlak, Lorenzo Sebastianelli, Veronica Egas Ortuno, Megha Karki, Yanfeng Xing, Jack W Szostak, Ramanarayanan Krishnamurthy, Sheref S Mansy

Open access · greenAbstract read
In one paragraph

Article in ACS nano, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Perspective: Protocells and the Path to Minimal Life.Journal of molecular evolution · 2024
    Review
  12. Protocellular Heme and Iron-Sulfur Clusters.Accounts of chemical research · 2024
    Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Ö Duhan ToparlakDepartment of Cellular, Computational and Integrative Biology, University of Trento, Via Sommarive 9, 38123 Povo, Trentino, Italy.
Lorenzo SebastianelliDepartment of Chemistry, University of Alberta, 11227 Saskatchewan Drive, Edmonton Alberta T6G 2G2, Canada.ORCID 0000-0001-5242-6335
Veronica Egas OrtunoDepartment of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
Megha KarkiDepartment of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
Yanfeng XingDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois 60637, United States.
Jack W SzostakHoward Hughes Medical Institute, Department of Chemistry, University of Chicago, Chicago, Illinois 60637, United States.ORCID 0000-0003-4131-1203
Ramanarayanan KrishnamurthyDepartment of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.ORCID 0000-0001-5238-610X
Sheref S MansyDepartment of Cellular, Computational and Integrative Biology, University of Trento, Via Sommarive 9, 38123 Povo, Trentino, Italy.ORCID 0000-0003-2382-198X
Scripps Research Institute · USUniversity of Alberta · CAHoward Hughes Medical Institute · USUniversity of Chicago · USUniversity of Trento · IT

Funding

Howard Hughes Medical Institute
6 · The paper itself

Abstract

There is currently no plausible path for the emergence of a self-replicating protocell, because prevalent formulations of model protocells are built with fatty acid vesicles that cannot withstand the concentrations of Mg

Indexed as

Artificial CellsNucleic AcidsCitratesFatty AcidsRNACitratesFatty AcidsNucleic AcidsRNAartificial cellscyclophospholipidsDarwinian evolutionprebiotic chemistryprotocells

Identifiers

PMID38038709
PMCPMC10722605
OpenAlexW4389245104

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.