Evidence map›Paper›PMID 38038481›Full record

ArticleJournal of clinical microbiology2023

Fecal calprotectin level is nonlinearly associated with GI pathogen detection in patients with and without inflammatory bowel disease.

Kira L Newman, Peter D R Higgins

Open access · greenAbstract read
In one paragraph

Article in Journal of clinical microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Kira L NewmanDepartment of Medicine, University of Michigan , Ann Arbor, Michigan, USA.ORCID 0000-0002-8279-1111
Peter D R HigginsDepartment of Medicine, University of Michigan , Ann Arbor, Michigan, USA.
University of Michigan · US

Funding

Training Program in Gastrointestinal EpidemiologyT32DK062708 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Peter D.R. Higgins, Elliot Tapper · 2003 to 2026
$3.9M
Training in Basic and Translational Digestive SciencesT32DK094775 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI JOHN Y KAO, LINDA C. SAMUELSON · 2012 to 2026
$3.6M
Measuring Molecular and Mechanical Outcomes of Endoscopic Dilation of Fibrotic StricturesR01DK125687 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Peter D.R. Higgins, Guan Xu · 2020 to 2026
$3.3M
Inhibiting Bcl-2-regulated intestinal fibrosis in models of Crohn’s DiseaseR01DK118154 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HIGGINS, PETER D.R. · 2018 to 2022
$2.3M
Bacterial, Viral, and Host Interactions in the Pathogenesis of Inflammatory Bowel DiseaseF32DK134043 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI NEWMAN, KIRA · 2022 to 2022
$81k
NIDDK NIH HHS F32 DK134043NIDDK NIH HHS R01 DK118154NIDDK NIH HHS R01 DK125687NIDDK NIH HHS T32 DK062708NIDDK NIH HHS T32 DK094775
6 · The paper itself

Abstract

Fecal calprotectin (FCP) is used to monitor inflammatory bowel disease (IBD) activity and can also be elevated in gastrointestinal infections. Our study's objective was to quantify the relationship between FCP levels and lab-confirmed infections in people with and without IBD. We performed a cross-sectional study at a tertiary-care center of all encounters during which FCP and gastrointestinal pathogen polymerase-chain reaction (GI PCR) panel testings were conducted. Using non-parametric tests and quantile regression, we compared the FCP levels by IBD status and pathogen detection. There were 3,347 encounters with FCP and GI PCR testings from 2,780 unique individuals between 1 August 2016 and 17 February 2022. Overall, 54.4% had IBD (

Indexed as

Inflammatory Bowel DiseasesLeukocyte L1 Antigen ComplexBiomarkersCross-Sectional StudiesFecesHumansBiomarkersLeukocyte L1 Antigen ComplexbiomarkersClostridium difficileCrohn’s diseaseEscherichia coliinfectious diarrheanorovirusulcerative colitis

Identifiers

PMID38038481
PMCPMC10729747
OpenAlexW4389223279

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.