Evidence map›Paper›PMID 38038476›Full record

ArticleAntimicrobial agents and chemotherapy2024

Loss-of-function mutations in

Sushil Pandey, Catherine Vilchèze, Jim Werngren, Arnold Bainomugisa, Mikael Mansjö, Ramona Groenheit, Paolo Miotto, Daniela M Cirillo, Christopher Coulter, Alain R Baulard and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Predicting isoniazid resistance inJournal of clinical microbiology · 2026
    Article
  3. A Comprehensive Review of Genetic Mechanisms ofInfection and drug resistance · 2026
    Review
  4. Antimicrobial agents and chemotherapy · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 6 countries.

Sushil Pandey *Queensland Mycobacterium Reference Laboratory, Pathology Queensland , Brisbane, Queensland, Australia.ORCID 0000-0002-7585-1040
Catherine Vilchèze *Department of Microbiology and Immunology, Albert Einstein College of Medicine , Bronx, New York, USA.ORCID 0000-0001-5960-6670
Jim Werngren *Public Health Agency of Sweden , Solna, Sweden.ORCID 0000-0003-2500-9792
Arnold BainomugisaQueensland Mycobacterium Reference Laboratory, Pathology Queensland , Brisbane, Queensland, Australia.ORCID 0000-0003-4180-6249
Mikael MansjöPublic Health Agency of Sweden , Solna, Sweden.ORCID 0000-0001-9289-351X
Ramona GroenheitPublic Health Agency of Sweden , Solna, Sweden.ORCID 0000-0003-2696-437X
Paolo MiottoEmerging Bacterial Pathogens Unit, IRCCS San Raffaele Scientific Institute , Milan, Italy.ORCID 0000-0003-4610-2427
Daniela M CirilloEmerging Bacterial Pathogens Unit, IRCCS San Raffaele Scientific Institute , Milan, Italy.ORCID 0000-0001-6415-1535
Christopher CoulterQueensland Mycobacterium Reference Laboratory, Pathology Queensland , Brisbane, Queensland, Australia.ORCID 0000-0003-2221-9946
Alain R BaulardUniv. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR9017 - CIIL - Center for Infection and Immunity of Lille , Lille, France.ORCID 0000-0002-0150-5241
Thomas SchönDepartment of Infectious Diseases, Linköping University Hospital , Linköping, Sweden.
William R JacobsDepartment of Microbiology and Immunology, Albert Einstein College of Medicine , Bronx, New York, USA.ORCID 0000-0003-3321-3080
Kamel Djaout *Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR9017 - CIIL - Center for Infection and Immunity of Lille , Lille, France.ORCID 0000-0003-1218-8031
Claudio U Köser *Department of Genetics, University of Cambridge , Cambridge, United Kingdom.ORCID 0000-0002-0232-846X
Public Health Agency of Sweden · SEQueensland Health · AUAlbert Einstein College of Medicine · USCentre National de la Recherche Scientifique · FRVita-Salute San Raffaele University · ITLinköping University · SEUniversity of Cambridge · GB

Funding

Molecular Genetic Analysis of Mycobacterium TuberculosisR37AI026170 · NIAID · ALBERT EINSTEIN COL OF MED YESHIVA UNIV · PI WILLIAM Robert JACOBS · 2004 to 2026
$7.7M
MOLECULAR GENETIC ANALYSIS OF MYCOBACTERIUM TUBERCULOSISR01AI026170 · NIAID · YESHIVA UNIVERSITY · PI JACOBS, WILLIAM ROBERT · 1989 to 2022
$7.1M
Generation of a Complete Set of Precise Null Bar-Coded Deletion Mutants of Mycobacterium tuberculosisR24AI134650 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI Shazia Hamid, WILLIAM Robert JACOBS · 2017 to 2026
$5.6M
NIAID NIH HHS R01 AI026170NIAID NIH HHS R24 AI134650NIAID NIH HHS R37 AI026170
6 · The paper itself

Abstract

Results from clinical strains and knockouts of the H37Rv and CDC1551 laboratory strains demonstrated that

Indexed as

Mycobacterium tuberculosisTuberculosis, Multidrug-ResistantAntitubercular AgentsBacterial ProteinsEthionamideHumansIsoniazidMutationNitroimidazolesOxazolesAntitubercular AgentsBacterial ProteinsEthionamideIsoniazidNitroimidazolesOPC-67683OxazolespretomaniddelamanidethionamideisoniazidMycobacterium tuberculosispretomanid

Identifiers

PMID38038476
PMCPMC10777854
OpenAlexW4389223255

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.