Evidence map›Paper›PMID 38038453›Full record

ArticleMicrobiology spectrum2024

The ER-Golgi transport of influenza virus through NS1-Sec13 association during virus replication.

Sonja C J H Chua, Jianzhou Cui, Karishma Sachaphibulkij, Isabelle Siang Ling Tan, Hui Qing Tan, Hong Meng Lim, David Engelberg, Lina H K Lim

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 2 countries.

Sonja C J H ChuaDepartment of Physiology, Yong Loo Lin School of Medicine, National University of Singapore , Singapore, Singapore.
Jianzhou CuiDepartment of Physiology, Yong Loo Lin School of Medicine, National University of Singapore , Singapore, Singapore.
Karishma SachaphibulkijDepartment of Physiology, Yong Loo Lin School of Medicine, National University of Singapore , Singapore, Singapore.
Isabelle Siang Ling TanDepartment of Physiology, Yong Loo Lin School of Medicine, National University of Singapore , Singapore, Singapore.
Hui Qing TanDepartment of Physiology, Yong Loo Lin School of Medicine, National University of Singapore , Singapore, Singapore.
Hong Meng LimDepartment of Physiology, Yong Loo Lin School of Medicine, National University of Singapore , Singapore, Singapore.
David EngelbergCREATE-NUS-HUJ Molecular Mechanisms of Inflammatory Diseases Programme, National University of Singapore , Singapore, Singapore.
Lina H K LimDepartment of Physiology, Yong Loo Lin School of Medicine, National University of Singapore , Singapore, Singapore.ORCID 0000-0002-2935-2275
National University of Singapore · SG

Funding

National Research Foundation Singapore (NRF) R185-000-352-592
6 · The paper itself

Abstract

importanceInfluenza A virus is a respiratory virus that can cause complications such as acute bronchitis and secondary bacterial pneumonia. Drug therapies and vaccines are available against influenza, albeit limited by drug resistance and the non-universal vaccine administration. Hence there is a need for host-targeted therapies against influenza to provide an effective alternative therapeutic target. Sec13 was identified as a novel host interactor of influenza. Endoplasmic reticulum-to-Golgi transport is an important pathway of influenza virus replication and viral export. Specifically, Sec13 has a functional role in influenza replication and virulence.

Indexed as

Influenza A virusInfluenza, HumanInfluenza VaccinesOrthomyxoviridaeGolgi ApparatusHumansVirus ReplicationInfluenza VaccinesCOPIIH1N1H3N2influenzanon-structural protein 1 (NS1)Sec13

Identifiers

PMID38038453
PMCPMC10782970
OpenAlexW4389223302

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.