Evidence map›Paper›PMID 38038410›Full record

ArticleeLife2023

Dynamic compartmentalization of the pro-invasive transcription factor NHR-67 reveals a role for Groucho in regulating a proliferative-invasive cellular switch in

Taylor N Medwig-Kinney, Brian A Kinney, Michael A Q Martinez, Callista Yee, Sydney S Sirota, Angelina A Mullarkey, Neha Somineni, Justin Hippler, Wan Zhang, Kang Shen and 3 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 3 citations in OpenAlex.

  1. Current Challenges of Transcription Compartmentalization Research.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Taylor N Medwig-KinneyDepartment of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, United States.ORCID 0000-0001-7989-3291
Brian A KinneyCold Spring Harbor Laboratory, Cold Spring Harbor, United States.ORCID 0000-0001-5628-1436
Michael A Q MartinezDepartment of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, United States.ORCID 0000-0003-1178-7139
Callista YeeHoward Hughes Medical Institute, Department of Biology, Stanford University, Stanford, United States.ORCID 0000-0002-2928-492X
Sydney S SirotaDepartment of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, United States.
Angelina A MullarkeyDepartment of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, United States.ORCID 0000-0002-5830-5347
Neha SomineniDepartment of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, United States.ORCID 0000-0001-5702-1695
Justin HipplerDepartment of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, United States.ORCID 0000-0002-7026-8761
Wan ZhangDepartment of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, United States.
Kang ShenHoward Hughes Medical Institute, Department of Biology, Stanford University, Stanford, United States.ORCID 0000-0003-4059-8249
Christopher HammellCold Spring Harbor Laboratory, Cold Spring Harbor, United States.ORCID 0000-0002-5961-0976
Ariel M PaniDepartments of Biology and Cell Biology, University of Virginia, Charlottesville, United States.
David Q MatusDepartment of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, United States.ORCID 0000-0002-1570-5025
Stony Brook University · USCold Spring Harbor Laboratory · USHoward Hughes Medical Institute · USUniversity of Virginia · US

Funding

Single-Cell Biology Shared ResourceP30CA045508 · NCI · COLD SPRING HARBOR LABORATORY · PI John Edward Moses · 1987 to 2026
$118.9M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
OSCILLATORY GENE EXPRESSION AND THE MAINTENANCE OF TEMPORAL PATTERNINGR01GM117406 · NIGMS · COLD SPRING HARBOR LABORATORY · PI HAMMELL, CHRISTOPHER MARTIN · 2016 to 2025
$4.0M
Dissecting the cell-biological foundations of developmental cell signaling in a living animalR35GM142880 · NIGMS · UNIVERSITY OF VIRGINIA · PI Ariel Matthew Pani · 2021 to 2026
$2.5M
Elucidating the mechanisms underlying cell cycle regulation of invasive behaviorR01GM121597 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI MATUS, DAVID · 2017 to 2021
$2.1M
Elucidating the Relationship Between Cell Proliferation and InvasionF30CA257383 · NCI · STATE UNIVERSITY NEW YORK STONY BROOK · PI MARTINEZ, MICHAEL ADRIAN · 2021 to 2024
$184k
Transcriptional regulation of morphogenetic behavior and invasive cell fate specification in C. elegansF31HD100091 · NICHD · STATE UNIVERSITY NEW YORK STONY BROOK · PI KINNEY, TAYLOR · 2019 to 2021
$117k
Damon Runyon Cancer Research Foundation DRR-47-17Howard Hughes Medical Institute InvestigatorNCI NIH HHS F30 CA257383NCI NIH HHS P30 CA045508NICHD NIH HHS F31 HD100091NIGMS NIH HHS R01 GM117406NIGMS NIH HHS R01 GM121597NIGMS NIH HHS R35 GM142880NIH HHS F30CA257383NIH HHS F31HD100091NIH HHS P40 OD010440NIH HHS R01GM117406NIH HHS R01GM121597NIH HHS R35GM142880
6 · The paper itself

Abstract

A growing body of evidence suggests that cell division and basement membrane invasion are mutually exclusive cellular behaviors. How cells switch between proliferative and invasive states is not well understood. Here, we investigated this dichotomy in vivo by examining two cell types in the developing

Indexed as

Caenorhabditis elegans ProteinsReceptors, Cytoplasmic and NuclearTranscription FactorsAnimalsBasic Helix-Loop-Helix ProteinsCaenorhabditis elegansCell DifferentiationGene Expression RegulationBasic Helix-Loop-Helix ProteinsCaenorhabditis elegans ProteinsHLH-2 protein, C elegansNhr-67 protein, C elegansReceptors, Cytoplasmic and NuclearTranscription Factorsunc-37 protein, C elegansC. eleganscell fatecell invasiondevelopmental biologytranscription factorstransdifferentiation

Identifiers

PMID38038410
PMCPMC10691804
OpenAlexW4323042101

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.