ArticleeLife2023
The genomic footprint of social stratification in admixing American populations.
Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- DiscoDivas: Leveraging genetic-ancestry continuum information to interpolate PRS for admixed populations.American journal of human genetics · 2026Article
- DiscoDivas: Leveraging genetic ancestry continuum information to interpolate PRS for admixed populations.medRxiv : the preprint server for health sciences · 2025Article
- Nested Admixture During and After the Trans-Atlantic Slave Trade on the Island of São Tomé.Molecular biology and evolution · 2025Article
- Insights from the Biorepository and Integrative Genomics pediatric resource.Nature communications · 2025Article
- Differentiating mechanism from outcome for ancestry-assortative mating in admixed human populations.Genetics · 2025Article
- The Biorepository and Integrative Genomics resource for inclusive genomics: insights from a diverse pediatric and admixed cohort.medRxiv : the preprint server for health sciences · 2025Article
- Differentiating mechanism from outcome for ancestry-assortative mating in admixed human populations.bioRxiv : the preprint server for biology · 2024Article
- Using the phenotype differences model to identify genetic effects in samples of partially genotyped sibling pairs.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Lupus and other autoimmune diseases: Epidemiology in the population of African ancestry and diagnostic and management challenges in Africa.The journal of allergy and clinical immunology. Global · 2024Review
- Genetic associations with disease in populations with Indigenous American ancestries.Genetics and molecular biology · 2024Article
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Authors and funding
3 authors.
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Abstract
Cultural and socioeconomic differences stratify human societies and shape their genetic structure beyond the sole effect of geography. Despite mating being limited by sociocultural stratification, most demographic models in population genetics often assume random mating. Taking advantage of the correlation between sociocultural stratification and the proportion of genetic ancestry in admixed populations, we sought to infer the former process in the Americas. To this aim, we define a mating model where the individual proportions of the genome inherited from Native American, European, and sub-Saharan African ancestral populations constrain the mating probabilities through ancestry-related assortative mating and sex bias parameters. We simulate a wide range of admixture scenarios under this model. Then, we train a deep neural network and retrieve good performance in predicting mating parameters from genomic data. Our results show how population stratification, shaped by socially constructed racial and gender hierarchies, has constrained the admixture processes in the Americas since the European colonization and the subsequent Atlantic slave trade.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.