Evidence map›Paper›PMID 38038253›Full record

ArticleJournal of veterinary internal medicine

Common and atypical presentations of Anaplasma phagocytophilum infection in equids with emphasis on neurologic and muscle disease.

Monica Aleman, Ujwala Vedavally, Nicola Pusterla, Fiona Wensley, Emily Berryhill, John E Madigan

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of veterinary internal medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Myosin Heavy Chain Myopathy and Immune-Mediated Muscle Disorders.The Veterinary clinics of North America. Equine practice · 2025
    Review
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Monica AlemanDepartment of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, California, USA.ORCID https://orcid.org/0000-0001-5811-9520
Ujwala VedavallyDepartment of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, California, USA.
Nicola PusterlaDepartment of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, California, USA.
Fiona WensleyWilliam R. Pritchard Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis, California, USA.
Emily BerryhillDepartment of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, California, USA.ORCID https://orcid.org/0000-0003-3160-6200
John E MadiganDepartment of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, California, USA.
University of California, Davis · USVeterinary Medical Teaching Hospital · US

Funding

Equine and Comparative Neurology Research Group at UCD (Aleman) #V435AM2
6 · The paper itself

Abstract

backgroundComprehensive descriptions of equids with granulocytic anaplasmosis (EGA) with neurologic or muscle disease and other atypical presentations are scarce in the literature.

objectiveDescribe the clinical signs, laboratory findings, treatment, and outcome of equids with EGA with emphasis on neurologic and muscle disease. ANIMALS: Thirty-eight horses, 1 donkey.

methodsRetrospective study. Equids with EGA were included. The electronic data base was searched from January 2000 to December 2022 using the words anaplasmosis, ehrlichiosis, granulocytic, and rickettsia. Signalment and clinical data were reviewed. Data were evaluated for normality using Shapiro-Wilk test. Parametric and nonparametric statistics were used for normally and non-normally distributed data.

resultsCommon (41%) and other (59%) presentations were seen in horses ≥ 4 years of age (median, 14 years) with an overrepresentation of males (77%). Neurologic disease was common (41%), mainly presenting as diffuse symmetrical proprioceptive ataxia. Brain disease was less common manifesting as obtundation and cranial nerve deficits. Muscle disease was less common, with QH breeds with the variant causing myosin heavy chain myopathy (MYHM) having severe disease. Cavitary effusion, cardiomyopathy and disseminated intravascular coagulation (DIC) were uncommon. Clinical laboratory results varied depending on disease stage. Muscle enzyme activities were significantly higher in horses with muscle disease. Outcome was favorable with prompt tetracycline treatment. Death and long-term sequelae were not reported. CONCLUSIONS AND CLINICAL IMPORTANCE: Common and atypical presentations of EGA have a favorable outcome with prompt tetracycline treatment. Quarter horse breeds with muscle disease should be genotyped for MYHM.

Indexed as

Anaplasma phagocytophilumAnaplasmosisEhrlichiosisHorse DiseasesMuscular DiseasesAnimalsAnti-Bacterial AgentsEquidaeHorsesMaleMusclesRetrospective StudiesTetracyclineAnti-Bacterial AgentsTetracyclineanaplasmosisehrlichiosisequinegranulocyticmorulae

Identifiers

PMID38038253
PMCPMC10800209
OpenAlexW4389244137

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.