ArticleJournal of global health2023
Epidemiological analysis reveals a surge in inflammatory bowel disease among children and adolescents: A global, regional, and national perspective from 1990 to 2019 - insights from the China study.
Article in Journal of global health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 27 citations in OpenAlex.
- Inflammatory bowel disease treatment: Mechanisms to clinical translation (Review).International journal of molecular medicine · 2026Review
- Paired mutation calling and spatial transcriptomics identify cellular neighborhoods associated with the neoplastic outcome of mouse colitis.Nature genetics · 2026Article
- The shifting burden of early-onset inflammatory bowel disease: a global analysis.Pediatric research · 2026Article
- Atopic Dermatitis and Risk of Inflammatory Bowel Disease in Children: A Systematic Review and Meta-Analysis.Cureus · 2026Review
- Subnational inequalities and preventable gaps in drowning premature mortality and non-fatal health loss among population younger than 20 years.Frontiers in public health · 2026Article
- The Escalating Global Burden of motor neuron disease: spatiotemporal trends among older adults, affected factors, and future projections.American journal of clinical and experimental immunology · 2026Article
- Targeting Gut Immune Dysregulation: Therapeutic Potential of Huangqin Decoction in Inflammatory Bowel Disease.Chinese journal of integrative medicine · 2025Review
- IL-26 from innate lymphoid cells regulates early-life gut epithelial homeostasis by shaping microbiota composition.The EMBO journal · 2025Article
- Children's hepatoblastoma: gender and infant age demand focus in the global burden of disease study 2021.Hepatology international · 2025Article
- The global burden of atrial fibrillation and atrial flutter in older adults (≥ 65 years): trends, disparities, and drivers (1990-2021).BMC cardiovascular disorders · 2025Article
- Inflammatory Bowel Disease in Indigenous Populations: A Scoping Review.Crohn's & colitis 360 · 2025Article
- Inflammatory bowel disease in paediatrics: Navigating the old challenges and emerging frontiers.World journal of gastroenterology · 2025Review
- Epidemiology and the cost burden of hospitalized pediatric-onset inflammatory bowel disease in China: A national database study.Pediatric investigation · 2025Article
- Temporal Trend and Health Inequality in the Burden of Autoimmune Diseases Among Older Adolescents and Young Adults Aged 15-29 Years.Archives of rheumatology · 2025Article
- The diagnostic value of ultrasound shear wave elastography combined with fecal biomarkers testing in children with inflammatory bowel disease.Pakistan journal of medical sciences · 2025Article
- Global, regional, and national burden for childhood and adolescent cancers from 1990 to 2021: from the Global Burden of Disease Study 2021.Pediatric surgery international · 2025Article
- Global, regional, and national burden of inflammatory bowel disease in persons aged 60-89 years from 1992 to 2021.BMC gastroenterology · 2025Article
- Neutrophils at the Crossroads of Inflammatory Bowel Disease and Atherosclerosis: A State-of-the-Art Review.Cells · 2025Review
- Joint Manifestations in Inflammatory Bowel Diseases, "Red Flags" for the Early Recognition and Management of Related Arthropathies: A Narrative Review.Journal of clinical medicine · 2025Review
- Global, Regional, and National Burdens of Inflammatory Bowel Disease in Women of Reproductive Age (15-49 Years) from 1992 to 2021.International journal of women's health · 2025Article
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The burden of inflammatory bowel disease (IBD) among children and adolescents is rising globally, with substantial variation in levels and trends of disease in different countries and regions, while data on the burden and trends were sparse in children and adolescents. We aimed to assess the trends and geographical differences in children and adolescents aged zero to 19 in 204 countries and territories over the past 30 years. Methods: Data on IBD among children and adolescents was collected from the Global Burden of Disease (GBD) 2019 database from 1990 to 2019. We used the GBD data and methodologies to describe the change in the burden of IBD among children and adolescents involving prevalence, incidence, disability-adjusted life years (DALYs), and mortality. Results: Globally, the IBD prevalence cases increased between 1990 and 2019. Annual percentage changes (AAPC) = 0.15; 95% confidence interval (CI) = 0.11-0.19, and incidence cases of IBD increased from 20 897.4 (95% CI = 17 008.6-25 520.2 in 1990 to 25 658.6 (95% CI = 21 268.5-31 075.6) in 2019, representing a 22.78% increase, DALYs cases decreased between 1990 and 2019 (AAPC = -3.02; 95% CI = -3.15 to -2.89), and mortality cases of IBD decreased from 2756.5 (95% CI = 1162.6-4484.9) in 1990 to 1208.0 (95% CI = 802.4-1651.4) in 2019, representing a 56.17% decrease. Decomposition analysis showed that IBD prevalence and incidence increased significantly, and a trend exhibited a decrease in underlying age and population-adjusted IBD DALYs and mortality rates. Correlation analysis showed that countries with high health care quality and access (HAQ) had relatively higher IBD age-standardised prevalence rate (ASPR) and age-standardised incidence rate (ASIR), but lower age-standardised DALYs rate (ASDR) and age-standardised mortality rate (ASMR). Conclusions: Global prevalence and incidence rate of IBD among children and adolescents have been increasing from 1990 to 2019, while the DALYs and mortality have been decreasing. Rising prevalence and rising incidence in areas with historically low rates will have crucial health and economic implications.
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