ArticleApplied magnetic resonance2023
In Vivo Myelin Water Quantification Using Diffusion-Relaxation Correlation MRI: A Comparison of 1D and 2D Methods.
Article in Applied magnetic resonance, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed.
- Short T1 Fraction as a Marker of Myelin Content: Evidence from Postmortem MRI and Histology.bioRxiv : the preprint server for biology · 2026Article
- Field Strength-Dependent White Matter RMagnetic resonance in medicine · 2026Article
- Phantom- and simulation-based validation of combined diffusion relaxometry in ex vivo ADRD white matter.bioRxiv : the preprint server for biology · 2026Article
- Maximum-entropy and subspace methods for high-resolution relaxation-diffusion distribution estimation.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Time-division multiplexing (TDM) sequence removes bias in TMagnetic resonance in medicine · 2024Article
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Authors and funding
11 authors.
Funding
Abstract
Multidimensional Magnetic Resonance Imaging (MRI) is a versatile tool for microstructure mapping. We use a diffusion weighted inversion recovery spin echo (DW-IR-SE) sequence with spiral readouts at ultra-strong gradients to acquire a rich diffusion-relaxation data set with sensitivity to myelin water. We reconstruct 1D and 2D spectra with a two-step convex optimization approach and investigate a variety of multidimensional MRI methods, including 1D multi-component relaxometry, 1D multi-component diffusometry, 2D relaxation correlation imaging, and 2D diffusion-relaxation correlation spectroscopic imaging (DR-CSI), in terms of their potential to quantify tissue microstructure, including the myelin water fraction (MWF). We observe a distinct spectral peak that we attribute to myelin water in multi-component T1 relaxometry, T1-T2 correlation, T1-D correlation, and T2-D correlation imaging. Due to lower achievable echo times compared to diffusometry, MWF maps from relaxometry have higher quality. Whilst 1D multi-component T1 data allows much faster myelin mapping, 2D approaches could offer unique insights into tissue microstructure and especially myelin diffusion.
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Registered trials
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