Evidence map›Paper›PMID 38037484›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024

Near Infrared Light-Activatable Platelet-Mimicking NIR-II NO Nano-Prodrug for Precise Atherosclerosis Theranostics.

Yun Chai, Lina Shangguan, Hui Yu, Ye Sun, Xiaoyan Huang, Yanyan Zhu, Hai-Yan Wang, Yi Liu

Open access · goldAbstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
5.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Therapeutic Gases in Biomedicine: Updates on Nitric Oxide and Beyond.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Nano Delivery System for Atherosclerosis.Journal of functional biomaterials · 2024
    Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Yun ChaiState Key Laboratory of Natural Medicines, School of Engineering, China Pharmaceutical University, Nanjing, 211198, China.
Lina ShangguanState Key Laboratory of Natural Medicines, School of Engineering, China Pharmaceutical University, Nanjing, 211198, China.
Hui YuState Key Laboratory of Natural Medicines, School of Engineering, China Pharmaceutical University, Nanjing, 211198, China.
Ye SunState Key Laboratory of Natural Medicines, School of Engineering, China Pharmaceutical University, Nanjing, 211198, China.
Xiaoyan HuangState Key Laboratory of Natural Medicines, School of Engineering, China Pharmaceutical University, Nanjing, 211198, China.
Yanyan ZhuState Key Laboratory of Natural Medicines, School of Engineering, China Pharmaceutical University, Nanjing, 211198, China.
Hai-Yan WangSchool of Mechanical Engineering, Southeast University, Nanjing, 211189, China.
Yi LiuState Key Laboratory of Natural Medicines, School of Engineering, China Pharmaceutical University, Nanjing, 211198, China.ORCID 0000-0001-5008-1097
China Pharmaceutical University · CNSoutheast University · CN

Funding

"Double First Class" University Project CPUQNJC22-03National Natural Science Foundation of China 82272148The 16th Six Talent Peaks Project of Jiangsu Province SWYY-063The Jiangsu Funding Program for Excellent Postdoctoral Talent 2022ZB301
6 · The paper itself

Abstract

Atherosclerosis is a chronic inflammatory disease that affects arteries and is the main cause of cardiovascular disease. Atherosclerotic plaque formation is usually asymptomatic and does not manifest until the occurrence of clinical events. Therefore, early diagnosis and treatment of atherosclerotic plaques is particularly important. Here, a series of NIR-II fluorescent dyes (RBT-NH) are developed for three photoresponsive NO prodrugs (RBT-NO), which can be controllably triggered by 808 nm laser to release NO and turn on the NIR-II emission in the clinical medicine "therapeutic window". Notably, RBT3-NO is selected for its exhibited high NO releasing efficiency and superior fluorescence signal enhancement. Subsequently, a platelet-mimicking nano-prodrug system (RBT3-NO-PEG@PM) is constructed by DSPE-mPEG

Indexed as

AtherosclerosisPlaque, AtheroscleroticProdrugsAnimalsMicePrecision MedicineProdrugsatherosclerosisnano-prodrugNIR-IInitric oxideplatelet-mimicking

Identifiers

PMID38037484
PMCPMC10797437
OpenAlexW4389244154

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.