ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024
Copper-Zinc-Doped Bilayer Bioactive Glasses Loaded Hydrogel with Spatiotemporal Immunomodulation Supports MRSA-Infected Wound Healing.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed.
- Bioactive glasses-mediated ion therapy ameliorates hepatic osteodystrophy by reprogramming the liver-bone axis.Bioactive materials · 2027Article
- Ultrasound-activated trilayer piezoelectric bio-adhesive for rapid repair and antibacterial treatment of gastrointestinal perforation.Bioactive materials · 2026Article
- Oriented hydrogel biomimicking muscle fibers to treat pelvic organ prolapse via integrated immunomodulation and electrical stimulation.Materials today. Bio · 2026Article
- A Self-Adaptive Programming Strategy Enables Local Microenvironment Modulation and Temporal Immunomodulation for Diabetic Infected Bone Regeneration.Advanced healthcare materials · 2026Article
- Nanomaterials-Based Immunotherapy for Atherosclerosis.Small (Weinheim an der Bergstrasse, Germany) · 2026Review
- Topical strategies for antimicrobial delivery of peptide medicines for the management of chronic wounds.Discover nano · 2026Review
- Targeting Golgi-STING Signaling to Reprogram Innate and Adaptive Immunity for the Treatment of Implant-Associated Infections.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Bioelectric Reawakening by a Self-Powered Thermoelectric Hydrogel Accelerates Diabetic Ulcer Repair.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Chitosan-Based Adhesive Composite Hydrogel to Provide Antibacterial and Anti-Inflammatory Properties for Biomedical Application.Gels (Basel, Switzerland) · 2026Article
- Temporal and spatial-adapted metal ions delivery system for spinal cord injury repair with Mg-Zn-doped bilayer bioactive glasses.Journal of nanobiotechnology · 2026Article
- Hydrogels for Bone Repair: Construction Strategies and Applications.Smart medicine · 2026Review
- Innovations in Implant Osseointegration: Biomaterials, Surface Engineering, and Translational Strategies.Journal of biomedical materials research. Part A · 2026Review
- Ionic-Bionic Interfaces: Advancing Iontronic Strategies for Bioelectronic Sensing and Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Construction of Skin-Adaptable Slide-Ring Hydrogels Based on Bile Acids Derived Polyrotaxanes for Smart Wound Dressing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Antimicrobial Hydrogel for Diabetic Wound Treatment.International journal of nanomedicine · 2026Review
- Single chiral center epimerization-modulated multi-carrier-free oral hydrogel for remolding inflammatory microenvironment via PI3K/Akt/NF-κB and MAPK signaling pathways.Bioactive materials · 2026Article
- Mesoporous Bioactive Glasses: A Powerful Tool in Tissue Engineering and Drug Delivery.Advanced healthcare materials · 2026Review
- The Multifaceted Properties of Copper and Zinc in Skin Healing.Dermatology and therapy · 2026Article
- Nanoparticles Targeting the Tumor Microenvironment for the Treatment of Osteosarcoma: Recent Progress and Perspectives.International journal of nanomedicine · 2026Review
- Adaptive hydrogel platforms for infected bone defect repair: microenvironmental responsiveness, osteoimmunomodulation, and regenerative remodeling.Frontiers in bioengineering and biotechnology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Developing biomaterials with antimicrobial and wound-healing activities for the treatment of wound infections remains challenging. Macrophages play non-negligible roles in healing infection-related wounds. In this study, a new sequential immunomodulatory approach is proposed to promote effective and rapid wound healing using a novel hybrid hydrogel dressing based on the immune characteristics of bacteria-associated wounds. The hydrogel dressing substrate is derived from a porcine dermal extracellular matrix (PADM) and loaded with a new class of bioactive glass nanoparticles (BGns) doped with copper (Cu) and zinc (Zn) ions (Cu-Zn BGns). This hybrid hydrogel demonstrates a controlled release of Cu
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.