Evidence map›Paper›PMID 38037132›Full record

ArticleArthritis research & therapy2023

The relation between synovitis of individual finger joints and grip force over the first 5 years in early rheumatoid arthritis - a cohort study.

Maria Rydholm, Ankita Sharma, Lennart Jacobsson, Carl Turesson

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arthritis research & therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06459453 (Effects of Kaltenborn Versus Mulligan Techniques on Pain, Range of Motion and Functional Disability in Patients With Rheumatoid Arthritis Of The Wrist.), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06459453 naunknown statusnot on this map

Effects of Kaltenborn Versus Mulligan Techniques on Pain, Range of Motion and Functional Disability in Patients With Rheumatoid Arthritis Of The Wrist.

TypeinterventionalSponsorRiphah International UniversityRan2023 to 2024Enrolled34ConditionsRheumatoid ArthritisArmsKaltenborn, Mulligan
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Maria RydholmRheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden.ORCID 0000-0002-9682-2070
Ankita SharmaRheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden.ORCID 0000-0001-5891-548X
Lennart JacobssonRheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden.ORCID 0000-0003-4402-148X
Carl TuressonRheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden. carl.turesson@med.lu.se.ORCID 0000-0002-3805-2290
Lund University · SEMalmö University · SE

Funding

Lunds Universitet ALFSKANE-446501Reumatikerförbundet R-664091Vetenskapsrådet 2015-02228
6 · The paper itself

Abstract

objectiveThe objective of this study was to investigate the relation between swelling and tenderness of individual finger joints and grip force in patients with early rheumatoid arthritis (RA).

methodsIn an inception cohort of patients with early RA (symptom duration < 12 months), all patients were examined by the same rheumatologist, and grip force was measured using the Grippit instrument at inclusion, 1 and 5 years. The average grip force values of each hand were evaluated and expressed as % of expected values, based on age- and sex-specific reference values. Linear regression analyses were used to assess the cross-sectional relation between the involvement of individual finger joints and grip force. In generalized estimating equations, the impact of time-varying synovitis/tenderness on grip force over time was estimated. Analyses were adjusted for wrist involvement, erythrocyte sedimentation rate, and patient-reported pain.

resultsIn 215 patients with early RA, grip force was 39% of expected at diagnosis, and increased to 56% after 5 years. Synovitis of the first metacarpophalangeal (MCP) joint (60% and 69% at baseline in the right and left hand) was associated with reduced grip force at inclusion (adjusted ß - 9.2 percentage unit of expected grip force; 95% CI - 13.6 to - 4.8 for both hands combined) and at all follow-up evaluations. Synovitis of MCP I and MCP IV (12% at baseline) was significantly associated with reduced grip force over time in both hands. Proximal interphalangeal (PIP) joint swelling, and tenderness of MCP or PIP joints, had less impact on grip force.

conclusionMCP I synovitis is the major contributor to reduced grip force in patients with early RA. This underlines the importance of the involvement of the thumb for impaired hand function in RA. MCP IV synovitis, but not PIP involvement or finger joint tenderness, also has a substantial impact on grip force.

Indexed as

Arthritis, RheumatoidSynovitisCohort StudiesCross-Sectional StudiesFemaleFinger JointHand StrengthHumansMaleFinger jointsHand strengthRheumatoid arthritisSynovitis

Identifiers

PMID38037132
PMCPMC10688125
OpenAlexW4389204730

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.