Evidence map›Paper›PMID 38037081›Full record

ArticleJournal of ovarian research2023

Adipose-derived exosomal miR-421 targets CBX7 and promotes metastatic potential in ovarian cancer cells.

Yi Zhang, Roslyn Tedja, Michael Millman, Terrence Wong, Alexandra Fox, Hussein Chehade, Meyer Gershater, Nicholas Adzibolosu, Radhika Gogoi, Matthew Anderson and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of ovarian research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Yi Zhang *Neurology, Henry Ford Health System, 2799 W Grand Blvd., Detroit, MI, 48202, USA. YZHANG3@hfhs.org.
Roslyn Tedja *C.S. Mott Center for Human Growth and Development, Department of Obstetrics and Gynecology, Wayne State University, 275 E. Hancock St., Detroit, MI, 48201, USA.
Michael MillmanNeurology, Henry Ford Health System, 2799 W Grand Blvd., Detroit, MI, 48202, USA.
Terrence WongC.S. Mott Center for Human Growth and Development, Department of Obstetrics and Gynecology, Wayne State University, 275 E. Hancock St., Detroit, MI, 48201, USA.
Alexandra FoxC.S. Mott Center for Human Growth and Development, Department of Obstetrics and Gynecology, Wayne State University, 275 E. Hancock St., Detroit, MI, 48201, USA.
Hussein ChehadeC.S. Mott Center for Human Growth and Development, Department of Obstetrics and Gynecology, Wayne State University, 275 E. Hancock St., Detroit, MI, 48201, USA.
Meyer GershaterC.S. Mott Center for Human Growth and Development, Department of Obstetrics and Gynecology, Wayne State University, 275 E. Hancock St., Detroit, MI, 48201, USA.
Nicholas AdzibolosuC.S. Mott Center for Human Growth and Development, Department of Obstetrics and Gynecology, Wayne State University, 275 E. Hancock St., Detroit, MI, 48201, USA.
Radhika GogoiC.S. Mott Center for Human Growth and Development, Department of Obstetrics and Gynecology, Wayne State University, 275 E. Hancock St., Detroit, MI, 48201, USA.
Matthew AndersonDepartment of Obstetrics and Gynecology, University of South Florida, Tampa, FL, USA.
Thomas RutherfordDepartment of Obstetrics and Gynecology, University of South Florida, Tampa, FL, USA.
Zhenggang ZhangNeurology, Henry Ford Health System, 2799 W Grand Blvd., Detroit, MI, 48202, USA.
Michael ChoppNeurology, Henry Ford Health System, 2799 W Grand Blvd., Detroit, MI, 48202, USA.
Gil MorC.S. Mott Center for Human Growth and Development, Department of Obstetrics and Gynecology, Wayne State University, 275 E. Hancock St., Detroit, MI, 48201, USA.
Ayesha B AlveroC.S. Mott Center for Human Growth and Development, Department of Obstetrics and Gynecology, Wayne State University, 275 E. Hancock St., Detroit, MI, 48201, USA. ayesha.alvero@wayne.edu.
Wayne State University · USHenry Ford Health System · USUniversity of South Florida · USOakland University · US

Funding

Targeting the vascularity for delivery of inhibitors of metastasis in ovarian cancer.R01CA199004 · NCI · YALE UNIVERSITY · PI LIU, HAIPENG, MOR, GIL G · 2015 to 2019
$2.5M
NCI NIH HHS R01 CA199004NIH HHS CA199004
6 · The paper itself

Abstract

backgroundChromobox protein homolog 7 (CBX7), a member of the Polycomb repressor complex, is a potent epigenetic regulator and gene silencer. Our group has previously reported that CBX7 functions as a tumor suppressor in ovarian cancer cells and its loss accelerated formation of carcinomatosis and drove tumor progression in an ovarian cancer mouse model. The goal of this study is to identify specific signaling pathways in the ovarian tumor microenvironment that down-regulate CBX7. Given that adipocytes are an integral component of the peritoneal cavity and the ovarian tumor microenvironment, we hypothesize that the adipose microenvironment is an important regulator of CBX7 expression.

resultsUsing conditioned media from human omental explants, we found that adipose-derived exosomes mediate CBX7 downregulation and enhance migratory potential of human ovarian cancer cells. Further, we identified adipose-derived exosomal miR-421 as a novel regulator of CBX7 expression and the main effector that downregulates CBX7.

conclusionIn this study, we identified miR-421 as a specific signaling pathway in the ovarian tumor microenvironment that can downregulate CBX7 to induce epigenetic change in OC cells, which can drive disease progression. These findings suggest that targeting exosomal miR-421 may curtail ovarian cancer progression.

Indexed as

MicroRNAsOvarian NeoplasmsAnimalsCell Line, TumorFemaleGene Expression Regulation, NeoplasticHumansMicePolycomb Repressive Complex 1Signal TransductionTumor MicroenvironmentCBX7 protein, humanMicroRNAsMIRN421 microRNA, humanPolycomb Repressive Complex 1

Identifiers

PMID38037081
PMCPMC10688490
OpenAlexW4389199663

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.