Evidence map›Paper›PMID 38036890›Full record

ReviewAdvances in experimental medicine and biology2024

Therapeutic Applications of Oxysterols and Derivatives in Age-Related Diseases, Infectious and Inflammatory Diseases, and Cancers.

Mohamed Ksila, Imen Ghzaiel, Khouloud Sassi, Amira Zarrouk, Valerio Leoni, Giuseppe Poli, Leila Rezig, Vivien Pires, Smail Meziane, Atanas G Atanasov and 9 more

Open access · bronzeAbstract readReview
PubMed Publisher
In one paragraph

Review in Advances in experimental medicine and biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
23.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 10 institutions in 4 countries.

Mohamed KsilaBio-PeroxIL Laboratory, EA7270, University of Bourgogne & Inserm, Dijon, France.
Imen GhzaielBio-PeroxIL Laboratory, EA7270, University of Bourgogne & Inserm, Dijon, France.
Khouloud SassiBio-PeroxIL Laboratory, EA7270, University of Bourgogne & Inserm, Dijon, France.
Amira ZarroukLaboratory of Rangeland Ecosystems and Valorization of Spontaneous Plants and Associated Microorganisms (LR16IRA03), Arid Regions Institute, University of Gabes, Medenine, Tunisia.
Valerio LeoniDepartment of Laboratory Medicine, University of Milano-Bicocca, Azienda Socio Sanitaria Territoriale Brianza ASST-Brianza, Desio Hospital, Desio, Italy.
Giuseppe PoliDepartment of Clinical and Biological Sciences, University of Turin, San Luigi Hospital, Turin, Italy.
Leila RezigUniversity of Carthage, National Institute of Applied Sciences and Technology, LR11ES26, LIP-MB 'Laboratory of Protein Engineering and Bioactive Molecules', Tunis, Tunisia.
Vivien PiresBio-PeroxIL Laboratory, EA7270, University of Bourgogne & Inserm, Dijon, France.
Smail MezianeInstitut Européen des Antioxydants (IEA), Neuves-Maisons, France.
Atanas G AtanasovInstitute of Genetics and Animal Biotechnology of the Polish Academy of Sciences, Magdalenka, Poland.
Sonia HammamiLaboratory of Rangeland Ecosystems and Valorization of Spontaneous Plants and Associated Microorganisms (LR16IRA03), Arid Regions Institute, University of Gabes, Medenine, Tunisia.
Mohamed HammamiLaboratory of Rangeland Ecosystems and Valorization of Spontaneous Plants and Associated Microorganisms (LR16IRA03), Arid Regions Institute, University of Gabes, Medenine, Tunisia.
Olfa Masmoudi-KoukiLaboratory of Neurophysiology, Cellular Physiopathology and Valorisation of Biomolecules (LR18ES03), Department of Biology, Faculty of Sciences, University Tunis El Manar, Tunis, Tunisia.
Oumaima HamdiUniversity Hospital Fattouma Bourguiba, Monastir, Tunisia.
Pierre JouannyPôle Personnes Agées, CHU de Dijon, Centre de Champmaillot, Dijon Cedex, France.
Mohammad SamadiLaboratory of Chemistry and Physics Multi-Scale Approach to Complex Environments, Department of Chemistry, University Lorraine, Metz, France.
Anne VejuxBio-PeroxIL Laboratory, EA7270, University of Bourgogne & Inserm, Dijon, France.
Taoufik GhrairiLaboratory of Neurophysiology, Cellular Physiopathology and Valorisation of Biomolecules (LR18ES03), Department of Biology, Faculty of Sciences, University Tunis El Manar, Tunis, Tunisia.
Gérard LizardBio-PeroxIL Laboratory, EA7270, University of Bourgogne & Inserm, Dijon, France. gerard.lizard@u-bourgogne.fr.
Inserm · FRTunis University · TNCHU Dijon Bourgogne · FRUniversity of Gabès · TNAzienda Socio Sanitaria Territoriale Lariana · ITHospital Fatuma Bourguiba Monastir · TNInstitute of Genetics and Animal Biotechnology of the Polish Academy of Sciences · PLLaboratoire d'Étude des Microstructures et de Mécanique des Matériaux · FRUniversity of Carthage · TNUniversity of Turin · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oxysterols, resulting from the oxidation of cholesterol, are formed either by autoxidation, enzymatically, or by both processes. These molecules, which are provided in more or less important quantities depending on the type of diet, are also formed in the body and their presence is associated with a normal physiological activity. Their increase and decrease at the cellular level and in biological fluids can have significant consequences on health due or not to the interaction of some of these molecules with different types of receptors but also because oxysterols are involved in the regulation of RedOx balance, cytokinic and non-cytokinic inflammation, lipid metabolism, and induction of cell death. Currently, various pathologies such as age-related diseases, inflammatory and infectious diseases, and several cancers are associated with abnormal levels of oxysterols. Due to the important biological activities of oxysterols, their interaction with several receptors and their very likely implications in several diseases, this review focuses on these molecules and on oxysterol derivatives, which are often more efficient, in a therapeutic context. Currently, several oxysterol derivatives are developed and are attracting a lot of interest.

Indexed as

Communicable DiseasesNeoplasmsOxysterolsAgingCholesterolHumansCholesterolOxysterolsAge-related diseasesAlzheimer’s diseaseCancerCardiovascular diseasesEye diseasesInfectious diseasesInflammatory diseasesOsteoporosisOxysterolsTherapeutic applications

Identifiers

PMID38036890
OpenAlexW4389208170

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.