ArticleNature methods2024
Improved green and red GRAB sensors for monitoring dopaminergic activity in vivo.
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Article in Nature methods, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers.
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102citing papers in PubMed
18.6field-weighted citation impact, top 1% of its field
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102 citing papers in PubMed, 121 citations in OpenAlex.
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- Illuminating the Future of Catecholamine Detection.Journal of neurochemistry · 2026Review
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- Depolarization block paradoxically drives surges of neurotransmitter release during seizure activity.Epilepsia · 2026Article
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- Leucine-rich repeat kinase 2 impairs the release sites of Parkinson's disease vulnerable dopamine axons.Nature communications · 2026Article
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- Protocol for simultaneous in vivo two-photon imaging and locomotion quantification during olfactory stimulation and pharmacology in walking Drosophila.STAR protocols · 2026Article
- A sensitive orange fluorescent calcium ion indicator for imaging neural activity.Nature communications · 2026Article
- A red-emitting, genetically encoded indicator for two-photon voltage recording in vivo.bioRxiv : the preprint server for biology · 2026Article
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42 more citing papers are in PubMed but not listed here.
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Authors and funding
23 authors at 6 institutions in 2 countries.
Yizhou Zhuo *State Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing, China.ORCID http://orcid.org/0000-0001-5359-8489
Bin Luo *State Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing, China.ORCID http://orcid.org/0000-0003-4989-8563
Xinyang YiState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing, China.ORCID http://orcid.org/0009-0006-5646-2791
Hui DongState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing, China.ORCID http://orcid.org/0000-0002-0563-3662
Xiaolei MiaoState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing, China.ORCID http://orcid.org/0000-0003-4445-9262
Jinxia WanState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing, China.ORCID http://orcid.org/0000-0001-5942-1465
John T WilliamsVollum Institute, Oregon Health & Science University, Portland, OR, USA.
Malcolm G CampbellCenter for Brain Science, Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA.
Ruyi CaiState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing, China.ORCID http://orcid.org/0000-0002-4674-4801
Tongrui QianState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing, China.ORCID http://orcid.org/0000-0002-0329-4687
Fengling LiShenzhen Key Laboratory of Drug Addiction, Shenzhen Neher Neural Plasticity Laboratory, the Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.ORCID http://orcid.org/0000-0002-7962-9033
Sophia J WeberDepartment of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR, USA.ORCID http://orcid.org/0000-0002-0845-7385
Lei WangState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing, China.
Bozhi LiState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing, China.
Yu WeiState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing, China.ORCID http://orcid.org/0009-0009-3673-4587
Guochuan LiState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing, China.
Huan WangState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing, China.ORCID http://orcid.org/0000-0002-7472-0057
Yu ZhengState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing, China.ORCID http://orcid.org/0009-0009-3930-4013
Yulin ZhaoState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing, China.ORCID http://orcid.org/0000-0003-1292-8618
Marina E WolfDepartment of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR, USA.
Yingjie ZhuShenzhen Key Laboratory of Drug Addiction, Shenzhen Neher Neural Plasticity Laboratory, the Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Mitsuko Watabe-UchidaCenter for Brain Science, Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-7864-754X
Yulong LiState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing, China. yulongli@pku.edu.cn.ORCID http://orcid.org/0000-0002-9166-9919
Peking University · CNOregon Health & Science University · USChinese Academy of Sciences · CNHarvard University · USCapital Medical University · CNMcGovern Institute for Brain Research · US
Funding
COCAINE: EFFECTS ON SINGLE NEURONSR01DA004523 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI WILLIAMS, JOHN T · 1987 to 2025
$7.6MNovel fluorescent sensors for imaging neuromodulationU01NS113358 · NINDS · UNIVERSITY OF CALIFORNIA BERKELEY · PI DAN, YANG, LI, YULONG · 2019 to 2022
$4.3MMolecular Codes for the Establishment of Functionally Segregated Dopaminergic CircuitsR01MH125162 · NIMH · BOSTON CHILDREN'S HOSPITAL · PI UMEMORI, HISASHI, WATABE-UCHIDA, MITSUKO · 2021 to 2025
$4.1MOptimization of GPCR-based fluorescent sensors for large-scale multiplexed in vivo imaging of neuromodulationU01NS120824 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HIRES, SAMUEL ANDREW, LI, YULONG · 2021 to 2024
$3.6MRetinoic acid, homeostatic plasticity and cocaine cravingR01DA049930 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI WOLF, MARINA ELIZABETH · 2020 to 2024
$2.5MDissecting the algorithmic and neural circuit basis of dopamine-driven learning in the striatumK99DA060290 · NIDA · HARVARD UNIVERSITY · PI CAMPBELL, MALCOLM GUY · 2024 to 2025
$240kNeural mechanisms of foraging decisionsF32MH126505 · NIMH · HARVARD UNIVERSITY · PI CAMPBELL, MALCOLM GUY · 2021 to 2023
$205kThe role of nucleus accumbens dopamine in incubation of cocaine cravingF31DA057063 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI WEBER, SOPHIA JIAHN · 2023 to 2024
$75kNIDA NIH HHS F31 DA057063NIDA NIH HHS K99 DA060290NIDA NIH HHS R01 DA004523NIDA NIH HHS R01 DA049930NIMH NIH HHS F32 MH126505NIMH NIH HHS R01 MH125162NINDS NIH HHS U01 NS113358NINDS NIH HHS U01 NS120824
Abstract
Dopamine (DA) plays multiple roles in a wide range of physiological and pathological processes via a large network of dopaminergic projections. To dissect the spatiotemporal dynamics of DA release in both dense and sparsely innervated brain regions, we developed a series of green and red fluorescent G-protein-coupled receptor activation-based DA (GRAB
Indexed as
DopamineNucleus AccumbensAnimalsBrainMiceReceptors, DopamineReceptors, G-Protein-CoupledDopamineReceptors, DopamineReceptors, G-Protein-Coupled
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