Evidence map›Paper›PMID 38036767›Full record

ArticleNature immunology2024

BCG vaccination stimulates integrated organ immunity by feedback of the adaptive immune response to imprint prolonged innate antiviral resistance.

Audrey Lee, Katharine Floyd, Shengyang Wu, Zhuoqing Fang, Tze Kai Tan, Heather M Froggatt, John M Powers, Sarah R Leist, Kendra L Gully, Miranda L Hubbard and 12 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 1 pooled it
13.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 1 synthesis or guideline pooled it, 81 citations in OpenAlex.

  1. Pooled it
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  4. Route of BCG administration determines success.Human vaccines & immunotherapeutics · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 4 institutions in 1 country.

Audrey LeeInstitute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford University, Stanford, CA, USA.
Katharine FloydDepartment of Pediatrics, Emory Vaccine Center, Emory National Primate Research Center, Emory University School of Medicine, Atlanta, GA, USA.ORCID 0000-0002-0866-6961
Shengyang WuInstitute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford University, Stanford, CA, USA.
Zhuoqing FangInstitute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford University, Stanford, CA, USA.ORCID 0000-0002-7418-1313
Tze Kai TanDepartment of Pathology, Stanford University School of Medicine, Stanford University, Stanford, CA, USA.
Heather M FroggattDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
John M PowersDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Sarah R LeistDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0002-4989-5381
Kendra L GullyDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Miranda L HubbardDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Chunfeng LiInstitute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford University, Stanford, CA, USA.
Harold HuiInstitute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford University, Stanford, CA, USA.
David ScovilleNanoString Technologies, Seattle, WA, USA.
Alistaire D RuggieroNanoString Technologies, Seattle, WA, USA.
Yan LiangNanoString Technologies, Seattle, WA, USA.ORCID 0000-0002-8536-5951
Anna PavenkoNanoString Technologies, Seattle, WA, USA.
Victor LujanInstitute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford University, Stanford, CA, USA.
Ralph S BaricDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0001-6827-8701
Garry P NolanDepartment of Pathology, Stanford University School of Medicine, Stanford University, Stanford, CA, USA.ORCID 0000-0002-8862-9043
Prabhu S ArunachalamInstitute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford University, Stanford, CA, USA.ORCID 0000-0003-0090-5689
Mehul S SutharDepartment of Pediatrics, Emory Vaccine Center, Emory National Primate Research Center, Emory University School of Medicine, Atlanta, GA, USA.
Bali PulendranInstitute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford University, Stanford, CA, USA. bpulend@stanford.edu.ORCID 0000-0001-6517-4333
Stanford University · USUniversity of North Carolina at Chapel Hill · USNanostring Technologies (United States) · USEmory University · US

Funding

Systems biological assessment of T cell responses to vaccinationU19AI167903 · NIAID · STANFORD UNIVERSITY · PI Holden T. Maecker · 2022 to 2026
$13.2M
MICROBES, DENDRITIC CELL SUBSETS AND T-CELL IMMUNITYR01AI048638 · NIAID · STANFORD UNIVERSITY · PI PULENDRAN, BALI · 2001 to 2024
$4.5M
Ultra high throughput sequencer for sustaining and enhancing multi-scale genomic studiesS10OD025212 · OD · STANFORD UNIVERSITY · PI SNYDER, MICHAEL P. · 2018 to 2018
$600k
30-parameter FACSymphony A3 flow cytometer for Shared Resource LabS10OD026831 · OD · STANFORD UNIVERSITY · PI NOLAN, GARRY P · 2019 to 2019
$510k
Computer ClusterS10OD021763 · OD · STANFORD UNIVERSITY · PI JI, HANLEE P · 2016 to 2016
$481k
Microbes, Dendritic Cell Subsets and T-Cell ImmunityR56AI048638 · NIAID · EMORY UNIVERSITY · PI PULENDRAN, BALI · 2008 to 2008
$440k
NIAID NIH HHS R01 AI048638NIAID NIH HHS R56 AI048638NIAID NIH HHS U19 AI167903NIH HHS S10 OD021763NIH HHS S10 OD025212NIH HHS S10 OD026831
6 · The paper itself

Abstract

Bacille Calmette-Guérin (BCG) vaccination can confer nonspecific protection against heterologous pathogens. However, the underlying mechanisms remain mysterious. We show that mice vaccinated intravenously with BCG exhibited reduced weight loss and/or improved viral clearance when challenged with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 B.1.351) or PR8 influenza. Protection was first evident between 14 and 21 d post-vaccination and lasted ∼3 months. Notably, BCG induced a biphasic innate response and robust antigen-specific type 1 helper T cell (T

Indexed as

Adaptive ImmunityBCG VaccineAnimalsAntiviral AgentsFeedbackHumansImmunity, InnateMiceSARS-CoV-2VaccinationWeight LossAntiviral AgentsBCG Vaccine

Identifiers

PMID38036767
PMCPMC10932731
OpenAlexW4389174060

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.