Evidence map›Paper›PMID 38036688›Full record

ArticleNatural products and bioprospecting2023

Kaemtakols A-D, highly oxidized pimarane diterpenoids with potent anti-inflammatory activity from Kaempferia takensis.

Orawan Jongsomjainuk, Jutatip Boonsombat, Sanit Thongnest, Hunsa Prawat, Paratchata Batsomboon, Sitthivut Charoensutthivarakul, Saroj Ruchisansakun, Kittipong Chainok, Jitnapa Sirirak, Chulabhorn Mahidol and 1 more

Abstract read
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In one paragraph

Article in Natural products and bioprospecting, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Orawan JongsomjainukLaboratory of Natural Products, Chulabhorn Research Institute, Bangkok, Thailand.
Jutatip BoonsombatLaboratory of Natural Products, Chulabhorn Research Institute, Bangkok, Thailand.
Sanit ThongnestLaboratory of Natural Products, Chulabhorn Research Institute, Bangkok, Thailand. sanit@cri.or.th.ORCID http://orcid.org/0000-0003-3824-2710
Hunsa PrawatLaboratory of Natural Products, Chulabhorn Research Institute, Bangkok, Thailand.
Paratchata BatsomboonLaboratory of Medicinal Chemistry, Chulabhorn Research Institute, Bangkok, Thailand.
Sitthivut CharoensutthivarakulExcellent Center for Drug Discovery (ECDD), School of Bioinnovation and Bio-Based Product Intelligence, and Center for Neuroscience, Faculty of Science, Mahidol University, Bangkok, Thailand.
Saroj RuchisansakunDepartment of Plant Science, Faculty of Science, Mahidol University, Bangkok, Thailand.
Kittipong ChainokThammasat University Research Unit in Multifunctional Crystalline Materials and Applications (TU-MCMA), Faculty of Science and Technology, Thammasat University, Pathum Thani, Thailand.
Jitnapa SirirakDepartment of Chemistry, Faculty of Science, Silpakorn University, Nakhon Pathom, Thailand.
Chulabhorn MahidolLaboratory of Natural Products, Chulabhorn Research Institute, Bangkok, Thailand.
Somsak RuchirawatLaboratory of Medicinal Chemistry, Chulabhorn Research Institute, Bangkok, Thailand.

Funding

Thailand Science Research and Innovation 36824/4274394Thailand Science Research and Innovation 36827/4274406
6 · The paper itself

Abstract

Four highly oxidized pimarane diterpenoids were isolated from Kaempferia takensis rhizomes. Kaemtakols A-C possess a tetracyclic ring with either a fused tetrahydropyran or tetrahydrofuran motif. Kaemtakol D has an unusual rearranged A/B ring spiro-bridged pimarane framework with a C-10 spirocyclic junction and an adjacent 1-methyltricyclo[3.2.1.0

Indexed as

Anti-inflammatoryDiterpenoidDP4+Kaempferia takensisMolecular dockingStructure elucidation

Identifiers

PMID38036688
PMCPMC10689700

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.