Evidence map›Paper›PMID 38036531›Full record

ArticleNature communications2023

How carvedilol does not activate β

Robert J Lefkowitz, Howard A Rockman, Paul J Shim, Samuel Liu, Seungkirl Ahn, Biswaranjan Pani, Sudarshan Rajagopal, Sudha K Shenoy, Michel Bouvier, Jeffrey L Benovic and 4 more

Open access · goldAbstract readLetterComment
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 3 countries.

Robert J LefkowitzDepartment of Medicine, Duke University, Durham, NC, USA. lefko001@receptor-biol.duke.edu.ORCID 0000-0003-1472-7545
Howard A RockmanDepartment of Medicine, Duke University, Durham, NC, USA. h.rockman@duke.edu.ORCID 0000-0003-2921-1584
Paul J ShimDepartment of Medicine, Duke University, Durham, NC, USA.ORCID 0000-0002-6610-8378
Samuel LiuDepartment of Medicine, Duke University, Durham, NC, USA.ORCID 0000-0001-8339-0080
Seungkirl AhnDepartment of Medicine, Duke University, Durham, NC, USA.ORCID 0000-0001-5681-3789
Biswaranjan PaniDepartment of Medicine, Duke University, Durham, NC, USA.
Sudarshan RajagopalDepartment of Medicine, Duke University, Durham, NC, USA.ORCID 0000-0002-3443-5040
Sudha K ShenoyDepartment of Medicine, Duke University, Durham, NC, USA.
Michel BouvierDepartment of Biochemistry and Molecular Medicine, Université de Montréal, Montreal, Quebec, Canada.ORCID 0000-0003-1128-0100
Jeffrey L BenovicDepartment of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA, USA.
Stephen B LiggettDepartments of Molecular Pharmacology and Medicine, University of South Florida College of Medicine, Tampa, FL, USA.ORCID 0000-0002-0128-3669
Robert R RuffoloResearch & Development, Wyeth Pharmaceuticals, Philadelphia, PA, USA.
Michael R BristowDepartment of Medicine, Division of Cardiology, University of Colorado - Anschutz Medical Campus, Aurora, CO, USA.ORCID 0000-0002-8860-4698
Milton PackerBaylor University Medical Center, Dallas, TX, USA.
Duke University · USBaylor University Medical Center · USHoward Hughes Medical Institute · USThomas Jefferson University · USUniversité de Montréal · CAUniversity of Colorado Anschutz Medical Campus · USUniversity of South Florida · US

Funding

MECHANISMS OF MALADAPTATION IN HEART FAILURER01HL056687 · NHLBI · UNIVERSITY OF NORTH CAROLINA CHAPEL HILL · PI Howard A Rockman · 1996 to 2026
$12.3M
Biasing CXCR3 Signaling to Modulate the Inflammatory ResponseR01GM122798 · NIGMS · DUKE UNIVERSITY · PI RAJAGOPAL, SUDARSHAN · 2017 to 2025
$3.2M
Regulation of myocardial GPCRs by USP20 in normal and hypertrophied heartR01HL160029 · NHLBI · DUKE UNIVERSITY · PI SHENOY, SUDHA K · 2021 to 2024
$2.2M
NHLBI NIH HHS R01 HL056687NHLBI NIH HHS R01 HL160029NIGMS NIH HHS R01 GM122798
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Adrenergic beta-AntagonistsReceptors, Adrenergic, beta-2CarvedilolAdrenergic beta-AntagonistsCarvedilolReceptors, Adrenergic, beta-2

Identifiers

PMID38036531
PMCPMC10689753
OpenAlexW4389204687

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.