Evidence map›Paper›PMID 38036289›Full record

ArticleThe Journal of investigative dermatology2024

Deciphering Tumor Cell Evolution in Cutaneous T-Cell Lymphomas: Distinct Differentiation Trajectories in Mycosis Fungoides and Sézary Syndrome.

Tony T Jiang, Simon Cao, Oleg Kruglov, Aman Virmani, Larisa J Geskin, Louis D Falo, Oleg E Akilov

Open access · greenAbstract read
In one paragraph

Article in The Journal of investigative dermatology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Immunopathogenesis of itch: an integrative framework for chronic pruritus.JID innovations : skin science from molecules to population health · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Tony T JiangDepartment of Dermatology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Simon CaoDepartment of Dermatology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Oleg KruglovDepartment of Dermatology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Aman VirmaniSchool of Art and Science, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Larisa J GeskinDepartment of Dermatology, Columbia University, New York, New York, USA.
Louis D FaloDepartment of Dermatology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Oleg E AkilovDepartment of Dermatology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. Electronic address: akilovoe@upmc.edu.
University of Pittsburgh · USColumbia University · US

Funding

Project 5: Microenvironment manipulation using anti-angiogenics to improve immunotherapy in melanomaP50CA254865 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DELGOFFE, GREG M., KIRKWOOD, JOHN MUNN · 2021 to 2025
$10.4M
NCI NIH HHS P50 CA254865
6 · The paper itself

Abstract

Cutaneous T-cell lymphomas are a heterogeneous group of neoplasms originating in the skin, with mycosis fungoides (MF) and Sézary syndrome (SS) representing the most common variants. The cellular origin of cutaneous lymphomas has remained controversial owing to their immense phenotypic heterogeneity that obfuscates lineage reconstruction on the basis of classical surface biomarkers. To overcome this heterogeneity and reconstruct the differentiation trajectory of malignant cells in MF and SS, TCR sequencing was performed in parallel with targeted transcriptomics at the single-cell resolution among cutaneous samples in MF and SS. Unsupervised lineage reconstruction showed that Sézary cells exist as a population of CD4

Indexed as

Cell DifferentiationMycosis FungoidesSezary SyndromeSkin NeoplasmsAgedCell ProliferationFemaleHumansLymphoma, T-Cell, CutaneousMaleMiddle AgedCutaneous lymphomaMycosis fungoidesProgenitorsSézary syndrome

Identifiers

PMID38036289
PMCPMC11034798
OpenAlexW4389081058

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.