ArticleBJS open2023
Tumour deposits in colon cancer predict recurrence and reduced survival in a nationwide population-based study.
Article in BJS open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 19 citations in OpenAlex.
- Tumor deposits on MRI in rectal cancer-detection and differentiation from lymph nodes with histopathological correlation.European radiology · 2026Article
- Prognostic importance of tumour deposits with and without concurrent lymph node metastases in patients with stage III colon cancer.BJS open · 2026Article
- A Critical Examination of the Changes Proposed by the AJCCCCEP for the AJCC 9th Edition Colorectal Cancer Staging System.The American journal of surgical pathology · 2026Article
- Article
- D3 lymph node dissection in right-sided colon cancer: routine requirement or selective application?Journal of gastrointestinal oncology · 2025Article
- Identifying occult high-risk features and stratified management strategies following curative resection for ampullary adenocarcinoma.Cancer biology & medicine · 2025Article
- Important role of tumor deposits and negative lymph nodes in prognosis of N1c colorectal cancer patients.World journal of gastroenterology · 2025Article
- Complete Mesocolic Excision for Colon Cancer: Insight into Potential Mechanisms of Oncologic Benefit.Cancers · 2025Review
- A prognostic nomogram based on desmoplastic reaction/tumor deposit modified lymph node staging in colorectal cancer.Journal of gastrointestinal oncology · 2025Article
- Factors associated with lymph node metastasis and survival in T2 colon cancer.BMC gastroenterology · 2025Article
- Important role of lymphovascular and perineural invasion in prognosis of colorectal cancer patients with N1c disease.World journal of gastroenterology · 2025Article
- Utilizing tumor deposit count as a stratification criterion in revising TNM staging system for patients with colorectal cancer: a nomogram review study.Frontiers in oncology · 2025Article
- Tumour deposit count is an independent prognostic factor in colorectal cancer-a population-based cohort study.The British journal of surgery · 2024Article
- Inhibitory Effects of the Polyphenols from the Root ofMolecules (Basel, Switzerland) · 2024Article
- Prognostic Value of Tumor Deposits in Patients with Colorectal Cancer.Journal of Cancer · 2024Article
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Authors and funding
4 authors at 1 institution in 1 country.
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Abstract
backgroundTumour deposits are suggested to impact prognosis in colon cancer negatively. This study assessed the impact of tumour deposits on oncological outcomes.
methodsData from the Swedish Colorectal Cancer Registry for patients who underwent R0 abdominal surgery for TNM stage I-III colon cancer between 2011 and 2014 with 5-year follow-up were analysed with multivariable analysis. Patients were categorized for their tumour deposit status and compared for the local recurrence and distant metastasis rates and 5-year survivals (overall and relative). Subgroup analyses were performed according to the nodal disease status.
resultsOf 8146 stage I-III colon cancer patients who underwent R0 resection, 8014 patients were analysed (808 tumour deposits positive, 7206 tumour deposits negative). Patients with tumour deposits positive tumours had increased local recurrence and distant metastasis rates (7.2 versus 3.0 per cent; P < 0.001 and 33.9 versus 12.0 per cent; P < 0.001 respectively) and reduced 5-year overall and relative survival (56.8 per cent versus 74.9 per cent; P < 0.001 and 68.5 versus 92.6 per cent; P < 0.001 respectively). In multivariable analysis, tumour deposits moderately increased the risks of local recurrence and distant metastasis (hazard ratio 1.50, 95 per cent c.i. 1.09 to 2.07; P = 0.013 and HR 1.91, 95 per cent c.i. 1.64 to 2.23; P < 0.001 respectively) and worse 5-year overall and relative survival (hazard ratio 1.60, 95 per cent c.i. 1.40 to 1.82; P < 0.001 and excess hazard ratio 2.24, 95 per cent c.i. 1.81 to 2.78; P < 0.001 respectively). Subgroup analysis of N stages found that N1c patients had worse outcomes than N0 for distant metastasis and relative survival. For patients with lymph node metastases tumour deposits increased the risks of distant metastasis and worse overall and relative survival, except for N2b patients.
conclusionTumour deposits negatively impact the prognosis in colon cancer and must be considered when discussing adjuvant chemotherapy.
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