Evidence map›Paper›PMID 38035327›Full record

ArticleFrontiers in cellular and infection microbiology2023

Revisiting bacterial cytolethal distending toxin structure and function.

Henry Chen, Claire J Ang, Molly K Crowder, William M Brieher, Steven R Blanke

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. International journal of microbiology · 2026
    Review
  3. Review
  4. Frontiers in microbiology · 2026
    Review
  5. Article
  6. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Henry ChenDepartment of Microbiology, School of Molecular and Cellular Biology, University of Illinois at Urbana-Champaign, Urbana, IL, United States.
Claire J AngDepartment of Microbiology, School of Molecular and Cellular Biology, University of Illinois at Urbana-Champaign, Urbana, IL, United States.
Molly K CrowderDepartment of Microbiology, School of Molecular and Cellular Biology, University of Illinois at Urbana-Champaign, Urbana, IL, United States.
William M BrieherDepartment of Cellular and Developmental Biology, University of Illinois at Urbana-Champaign, Urbana, IL, United States.
Steven R BlankeDepartment of Microbiology, School of Molecular and Cellular Biology, University of Illinois at Urbana-Champaign, Urbana, IL, United States.
University of Illinois Urbana-Champaign · US

Funding

Actin Assembly at Cadherin Dependent Adherens JunctionsR01GM106106 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI BRIEHER, WILLIAM · 2013 to 2022
$2.6M
Cellular Intoxication Pathway of Cytolethal Distending ToxinR01GM098756 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BRADLEY, KENNETH ALAN · 2011 to 2014
$1.8M
C. jejuni Cytolethal Distending Toxin Cell InteractionsR21AI059095 · NIAID · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI BLANKE, STEVEN R. · 2004 to 2005
$528k
Cytolethal Distending Toxin and Intestinal HomeostasisR21AI144544 · NIAID · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI BLANKE, STEVEN R. · 2021 to 2022
$402k
NIAID NIH HHS R21 AI059095NIAID NIH HHS R21 AI144544NIGMS NIH HHS R01 GM098756NIGMS NIH HHS R01 GM106106
6 · The paper itself

Abstract

Cytolethal distending toxins (CDTs) are intracellular-acting bacterial genotoxins generated by a diverse group of mucocutaneous human pathogens. CDTs must successfully bind to the plasma membrane of host cells in order to exert their modulatory effects. Maximal toxin activity requires all three toxin subunits, CdtA, CdtB, and CdtC, which, based primarily on high-resolution structural data, are believed to preassemble into a tripartite complex necessary for toxin activity. However, biologically active toxin has not been experimentally demonstrated to require assembly of the three subunits into a heterotrimer. Here, we experimentally compared concentration-dependent subunit interactions and toxin cellular activity of the

Indexed as

Bacterial ToxinsCampylobacter jejuniCell CycleEdetic AcidHumansBacterial ToxinsCDTAcytolethal distending toxinEdetic AcidAB toxinCampylobacter jejunicytolethal distending toxinDNA damageholotoxin structureprotein-protein interactions

Identifiers

PMID38035327
PMCPMC10682658
OpenAlexW4388657312

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.