Evidence map›Paper›PMID 38035298›Full record

ArticleFrontiers in public health2023

Race and sex differences in the association between lifespan glycemic status and midlife cognitive function: the Bogalusa heart study.

Kathryn L Gwizdala, Lydia A Bazzano, Robert L Newton, Owen T Carmichael

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in public health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Kathryn L GwizdalaPhysical Activity and Ethnic Minority Health Laboratory, Department of Population and Public Health Sciences, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, United States.
Lydia A BazzanoTulane Center for Lifespan Epidemiology Research, Tulane University School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, United States.
Robert L NewtonPhysical Activity and Ethnic Minority Health Laboratory, Department of Population and Public Health Sciences, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, United States.
Owen T CarmichaelBiomedical Imaging Center, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, United States.
Louisiana State University System · USPennington Biomedical Research Center · USTulane University · US

Funding

Supplemental Funding Request for RF1 AG062309 Early life glycemic status and Alzheimer's disease neuroimaging markers in middle age: the Bogalusa Heart StudyR01AG062309 · NIA · TULANE UNIVERSITY OF LOUISIANA · PI BAZZANO, LYDIA, CARMICHAEL, OWEN T. · 2019 to 2023
$3.9M
The Role of Vascular Aging in Cognitive and Physical Function - Diversity SupplementR01AG041200 · NIA · TULANE UNIVERSITY OF LOUISIANA · PI BAZZANO, LYDIA · 2012 to 2017
$2.9M
NIA NIH HHS R01 AG041200NIA NIH HHS R01 AG062309
6 · The paper itself

Abstract

Introduction: Glycemic markers throughout life are associated with increased risk of midlife cognitive decline, yet it is unclear whether these associations differ by race and sex. Methods: This study used cross-sectional analysis of prospectively maintained cohort. 1,295 participants in the Bogalusa Heart Study, a biracial epidemiological cohort located in a micropolitan area core setting, provided fasting plasma insulin (FPI) and glucose (FPG) biannually from 1973 to 2016. Memory, executive function (EF), attention, working memory (WM), and global cognition (GC), collected 2013-2016. Glycemic markers (i.e., FPG, FPI, and HOMA-IR) averaged within lifespan epochs (≤ 20 years, childhood/adolescence (C/A); 21-40 years, early adulthood (EA); and 40-58 years, midlife). Linear regression models were analyzed for each epoch and separate models were analyzed with sex and race, education as a covariate. Results: Sample was 59% women, 34% African American (AA). Among women, higher C/A FPG was associated with poorer memory and poorer GC. Higher EA FPG was associated with poorer WM. Among men, higher EA HOMA-IR was associated with worse attention. Higher C/A HOMA-IR and FPI were associated with Discussion: Markers indicative of hyperglycemia at different epochs were associated with worse midlife cognition in women, AAs, and WAs; but not in men. Differences in the relationship between lifespan glycemic exposures and midlife cognition could reflect broader health disparities.

Indexed as

Blood GlucoseInsulin ResistanceAdolescentAdultChildCognitionCross-Sectional StudiesFemaleHumansLongevityLongitudinal StudiesMaleRacial GroupsSex CharacteristicsBlood Glucosecognitive functionglucoseinsulinracesex

Identifiers

PMID38035298
PMCPMC10684774
OpenAlexW4388701814

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.