Evidence map›Paper›PMID 38035225›Full record

ArticleSurgery open science2023

Development of male and female models of long urethral strictures in swine.

Gokhan Gundogdu, Travis Nguyen, Mando Eijansantos, Ambika Chaudhuri, David Barham, Joel Gelman, Joshua R Mauney

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Surgery open science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Gokhan GundogduDepartment of Urology, University of California, Irvine, Orange, CA 92868, USA.
Travis NguyenDepartment of Biomedical Engineering, University of California, Irvine, Irvine, CA 92617, USA.
Mando EijansantosDepartment of Biomedical Engineering, University of California, Irvine, Irvine, CA 92617, USA.
Ambika ChaudhuriDepartment of Biomedical Engineering, University of California, Irvine, Irvine, CA 92617, USA.
David BarhamDepartment of Urology, University of California, Irvine, Orange, CA 92868, USA.
Joel GelmanDepartment of Urology, University of California, Irvine, Orange, CA 92868, USA.
Joshua R MauneyDepartment of Urology, University of California, Irvine, Orange, CA 92868, USA.
University of California, Irvine · US

Funding

Drug Eluting Silk Fibroin Grafts for Repair of Long Urethral StricturesR01DK131211 · NIDDK · UNIVERSITY OF CALIFORNIA-IRVINE · PI Joshua Robert Mauney · 2023 to 2026
$2.5M
Partial Bladder Outlet Obstruction: Mechanisms of Injury and Novel Repair StrategiesR01DK119240 · NIDDK · UNIVERSITY OF CALIFORNIA-IRVINE · PI ESTRADA, CARLOS R, MAUNEY, JOSHUA ROBERT · 2019 to 2023
$1.6M
NIDDK NIH HHS R01 DK119240NIDDK NIH HHS R01 DK131211
6 · The paper itself

Abstract

Background: Preclinical animal models which mimic the dimensions of long urethral strictures (>2 cm in length) encountered in the clinic are necessary to evaluate prospective graft designs for urethroplasty. The purpose of this study was to develop both male and female porcine models of long urethral strictures (∼4 cm in length) and characterize histological and functional outcomes of iatrogenic stricture formation between genders. Methods: Focal, partial thickness urethral injuries were created over 5-6 cm long segments in male and female swine ( Results: Urethral stricture formation was detected in all female swine by 2 weeks and 100 % of male swine at 3.2 ± 1.8 weeks, post-operatively. The mean length of urethral strictures in both male and female swine was ∼4 cm. Substantial variations in the degree of stricture severity between sexes were observed with males exhibiting significant urethral stenosis and loss of α-smooth muscle actin+ smooth muscle bundles in comparison to controls, while females primarily displayed defects in pan-cytokeratin+ epithelia as well as functional urethral obstruction. Conclusions: Electrocoagulation injury is sufficient to produce long urethral strictures in male and female swine and the degree of stricture severity and nature of urethral obstruction was observed to be dependent on gender. Animal Protocol: AUP-19-150. Key message: Novel male and female models of long urethral strictures in swine were created to characterize histological and functional outcomes of iatrogenic stricture formation between genders.

Indexed as

SwineTissue engineeringUrethral strictureWound healing

Identifiers

PMID38035225
PMCPMC10687041
OpenAlexW4388817477

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.