Evidence map›Paper›PMID 38035181›Full record

ArticleLeukemia research reports2023

Cytogenetic abnormalities correlate with clinico-biological characteristics in 30 Moroccan multiple myeloma patients.

Hasna Hamdaoui, Badreddine Nouadi, Oumaima Benlarroubia, Faiza Chbel, Chaimaa Saadoune, Faïza Bennis, Afaf Lamzouri, Fatima Chegdani

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Leukemia research reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 62% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Hasna HamdaouiMedical Genetics and Oncogenetics Laboratory, Mohammed VI University Hospital Center, Tangier, Morocco.
Badreddine NouadiImmunology and Biodiversity Laboratory, Faculty of Sciences Aïn Chock, Hassan II University of Casablanca, Morocco.
Oumaima BenlarroubiaNational Reference Laboratory, Mohammed VI University of Health Sciences (UM6SS), Casablanca, Morocco.
Faiza ChbelLaboratory of Geosciences and Materials Engineering, École Normale Supérieure, Hassan II University of Casablanca, Morocco.
Chaimaa SaadouneImmunology and Biodiversity Laboratory, Faculty of Sciences Aïn Chock, Hassan II University of Casablanca, Morocco.
Faïza BennisImmunology and Biodiversity Laboratory, Faculty of Sciences Aïn Chock, Hassan II University of Casablanca, Morocco.
Afaf LamzouriMedical Genetics and Oncogenetics Laboratory, Mohammed VI University Hospital Center, Tangier, Morocco.
Fatima ChegdaniImmunology and Biodiversity Laboratory, Faculty of Sciences Aïn Chock, Hassan II University of Casablanca, Morocco.
University of Hassan II Casablanca · MAUniversité Mohammed VI des Sciences et de la Santé · MAAbdelmalek Essaâdi University · MAÉcole Normale Supérieure Casablanca · MA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The nonrandom recurrence of chromosomal abnormalities in multiple myeloma (MM) raises the possibility that they play a role in the pathophysiology and development of the disease. Fluorescence in situ hybridization (FISH) can identify a high frequency of certain abnormalities without the need for the proliferative and infiltrative index of malignant plasma cells required for conventional cytogenetic analysis. In this study, we describe the association between clinico-biological characteristics and chromosomal abnormalities in 30 Moroccan patients. Methods: The analysis of cytogenetic data, conventional and molecular, of 30 cases of MM, obtained from our previously cytogenetic study, and correlation of the results with the clinico-biological data of these patients. Results: The bone marrow of 5 of 21 patients (23 %) contained a chromosomally abnormal clone, and all karyotypes were complicated (>3 abnormalities). Interphase FISH (iFISH) has detected aberrations in 14 out of 30 (46 %) of the total cases. The proportion of plasma cells in the bone marrow was higher in patients with chromosomal abnormalities (median 29 %) ( Conclusion: Our research has shown that different subgroups of patients with MM can be classified based on the underlying genetic abnormalities. Chromosomal abnormalities (CA) may give the plasma cell a proliferative advantage, increasing the virulence of the disease and affecting overall survival.

Indexed as

Chromosomal abnormalitiesClinic-biological characteristicsFluorescence in situ hybridization (FISH)Multiple myeloma

Identifiers

PMID38035181
PMCPMC10685041
OpenAlexW4387967146

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.