SynthesisFrontiers in psychiatry2023
Neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, and monocyte to lymphocyte ratio in ADHD: a systematic review and meta-analysis.
Synthesis in Frontiers in psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Peripheral Inflammation In Adult ADHD: Sex Differences And Hematological Markers.The Psychiatric quarterly · 2026Article
- Clinical Characteristics and Blood-Based Inflammatory Indices of Psychiatric Hospitalizations Among Children with Autism in China: A Retrospective Electronic Medical Records Study.Brain sciences · 2026Article
- Haematological Inflammatory Indices in Preschoolers With Developmental Language Disorder: The Role of the Systemic Inflammation Response Index.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2026Article
- Peripheral Hematological and Immune-Endocrine Markers in Children with Specific Learning Disorder: An Exploratory Retrospective Case-Control Study.Brain sciences · 2026Article
- C-Reactive Protein and Neutrophil-To-Lymphocyte Ratio: Can They Be Used Interchangeably in Tracking Clozapine-Related Inflammation?Pharmacotherapy · 2026Article
- Comparison of inflammatory and ECG markers between children/adolescents with ADHD and healthy controls.Frontiers in psychiatry · 2026Article
- Cognitive profile and inflammatory markers in children and adolescents with specific learning disorder: a cross-sectional study.Frontiers in pediatrics · 2026Article
- The neutrophil-to-lymphocyte ratio as a predictor of all-cause mortality in individuals with anemia: A population-based study.PloS one · 2026Article
- Hematological Inflammatory Markers Across Neurodevelopmental Disorders: Preliminary Findings of an Observational Retrospective Study.Brain sciences · 2025Article
- The role of inflammation in the development of tic symptoms in subjects with ADHD.Brain, behavior, & immunity - health · 2025Article
- Research advances and future directions in female ADHD: the lifelong interplay of hormonal fluctuations with mood, cognition, and disease.Frontiers in global women's health · 2025Review
- Machine learning-guided feature selection and predictive model construction for attention-deficit/hyperactivity disorder.Frontiers in psychiatry · 2025Article
- Novel hematologic ratios and systemic inflammation index in ADHD: effects of methylphenidate treatment.Frontiers in psychiatry · 2025Article
- Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte Ratio in ADHD: A Systematic Scoping Review.Advances in neurodevelopmental disorders · 2024Article
- Urinary Histamine Not Associated with Severity of Symptoms of ADHD and Emotional Dysregulation: A Cross-sectional Secondary Data Analysis from the Micronutrients for ADHD in Youth (MADDY) Study.Advances in neurodevelopmental disorders · 2024Article
- Identification of immune traits associated with neurodevelopmental disorders by two-sample Mendelian randomization analysis.BMC psychiatry · 2024Article
- Inflammatory Hematological Ratios in Adolescents with Mental Disorders: A Scoping Review.Consortium psychiatricum · 2024Article
- Association between Monocyte-to-Lymphocyte Ratio and Inflammation in Chronic Kidney Disease: A Cross-Sectional Study.Kidney & blood pressure research · 2024Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Attention-deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder with an unclear etiology. Systemic inflammation and immune dysregulation may play a role in the pathogenesis of ADHD. Morphology-derived parameters such as neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and monocyte to lymphocyte ratio (MLR), have been proposed as peripheral biomarkers of the immune-inflammatory process in various diseases. However, studies examining their role in ADHD remain inconclusive. Methods: A systematic review and a meta-analysis were conducted to evaluate the association between NLR, MLR, PLR and ADHD. Relevant articles were identified, screened, and assessed for quality according to PRISMA guidelines. Moreover, a qualitative and quantitative analyses were performed. Results: The review contained eight eligible studies, five of which were included in the meta-analysis. The meta-analysis showed that ADHD patients had higher NLR and PLR values compared to health controls. No significant difference in MLR value was observed between the two groups. Analysis in relation to ADHD subtypes showed no significant differences in inflammatory markers in any of the included studies as well. The influence of medical treatment on these ratios could not be adequately assessed due to limited data. Conclusion: ADHD patients exhibit higher NLR and PLR than healthy controls, which may indicate the potential immune-inflammatory involvement in this disorder. Further studies on inflammatory markers and ADHD, especially those considering the impact of treatment and clinical symptoms, are essential to comprehensively understand this association.
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