Evidence map›Paper›PMID 38034894›Full record

ArticleHeart rhythm O22023

Association of pre-left ventricular assist device defibrillator shocks for ventricular arrhythmia with clinical outcomes after left ventricular assist device implantation.

Daniel G Wann, Andrew S Baird, Norman C Wang, Suresh R Mulukutla, Floyd W Thoma, Ahmet Sezer, Ann M Canterbury, Amr F Barakat, Michael W Gardner, Jenna N Skowronski and 10 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heart rhythm O2, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 4 institutions in 1 country.

Daniel G WannHeart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Andrew S BairdDivision of Cardiovascular Medicine, University of Utah, Salt Lake City, Utah.
Norman C WangHeart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Suresh R MulukutlaHeart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Floyd W ThomaHeart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Ahmet SezerHeart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Ann M CanterburyHeart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Amr F BarakatCardiology Department, Ascension St. Vincent's Medical Center, Jacksonville, Florida.
Michael W GardnerCardiology Department, Adventist Health, Portland, Oregon.
Jenna N SkowronskiHeart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Konstantinos N AronisHeart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Andrew H VoigtHeart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Sandeep K JainHeart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Samir F SabaHeart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Aditya BhonsaleHeart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
N A Mark EstesHeart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Mary E KeeblerHeart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Gavin W HickeyHeart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Raveen R BazazHeart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Krishna KancharlaHeart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
University of Pittsburgh Medical Center · USAdventist HealthCare · USSt. Vincent's Medical Center · USUniversity of Utah · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Implantable cardioverter-defibrillation (ICD) shocks after left ventricular assist device therapy (LVAD) are associated with adverse clinical outcomes. Little is known about the association of pre-LVAD ICD shocks on post-LVAD clinical outcomes and whether LVAD therapy affects the prevalence of ICD shocks. Objectives: The purpose of this study was to determine whether pre-LVAD ICD shocks are associated with adverse clinical outcomes post-LVAD and to compare the prevalence of ICD shocks before and after LVAD therapy. Methods: Patients 18 years or older with continuous-flow LVADs and ICDs were retrospectively identified within the University of Pittsburgh Medical Center system from 2006-2020. We analyzed the association between appropriate ICD shocks within 1 year pre-LVAD with a primary composite outcome of death, stroke, and pump thrombosis and secondary outcomes of post-LVAD ICD shocks and ICD shock hospitalizations. Results: Among 309 individuals, average age was 57 ± 12 years, 87% were male, 80% had ischemic cardiomyopathy, and 42% were bridge to transplantation. Seventy-one patients (23%) experienced pre-LVAD shocks, and 69 (22%) experienced post-LVAD shocks. The overall prevalence of shocks pre-LVAD and post-LVAD were not different. Pre-LVAD ICD shocks were not associated with the composite outcome. Pre-LVAD ICD shocks were found to predict post-LVAD shocks (hazard ratio [HR] 5.7; 95% confidence interval [CI] 3.42-9.48; Conclusion: Pre-LVAD ICD shocks predicted post-LVAD ICD shocks and hospitalizations but were not associated with the composite outcome of death, pump thrombosis, or stroke at 1 year. The prevalence of appropriate ICD shocks was similar before and after LVAD implantation in the entire cohort.

Indexed as

Assist deviceDefibrillationHeart failureMechanical supportVentricular tachycardia

Identifiers

PMID38034894
PMCPMC10685166
OpenAlexW4387644088

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.