Evidence map›Paper›PMID 38034776›Full record

ArticleHeliyon2023

The study of therapeutic efficacy and mechanisms of

Qingyu Cao, Jiaqi Liu, Chengguo Pang, Kemeng Liu, Ruijiao Wang, Yuanjin Chen, Xu Yuan, Meng Zhang, Jiating Ni, Peiliang Dong and 1 more

Open access · goldAbstract read
In one paragraph

Article in Heliyon, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Evaluation of the Anti-Alzheimer Activity ofCurrent issues in molecular biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Qingyu CaoInstitute of Chinese Medicine, Heilongjiang University of Chinese Medicine, Harbin 150000, China.
Jiaqi LiuInstitute of Chinese Medicine, Heilongjiang University of Chinese Medicine, Harbin 150000, China.
Chengguo PangCollege of Medicine, Heilongjiang University of Chinese Medicine, Harbin 150000, China.
Kemeng LiuInstitute of Chinese Medicine, Heilongjiang University of Chinese Medicine, Harbin 150000, China.
Ruijiao WangCollege of Medicine, Heilongjiang University of Chinese Medicine, Harbin 150000, China.
Yuanjin ChenInstitute of Chinese Medicine, Heilongjiang University of Chinese Medicine, Harbin 150000, China.
Xu YuanCollege of Medicine, Heilongjiang University of Chinese Medicine, Harbin 150000, China.
Meng ZhangCollege of Medicine, Heilongjiang University of Chinese Medicine, Harbin 150000, China.
Jiating NiCollege of Medicine, Heilongjiang University of Chinese Medicine, Harbin 150000, China.
Peiliang DongInstitute of Chinese Medicine, Heilongjiang University of Chinese Medicine, Harbin 150000, China.
Hua HanCollege of Medicine, Heilongjiang University of Chinese Medicine, Harbin 150000, China.
Heilongjiang University of Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Methods: High-performance liquid chromatography was employed to analyze the primary active constituents of Schisandra and Evodia. The effects of the combined treatment of Schisandra and Evodia on learning and memory in an Alzheimer's disease rat model were evaluated through Morris water maze and Hematoxylin-Eosin staining experiments. Immunohistochemical analysis was conducted to investigate the impact of S-E on Aβ Results: The treatment group exhibited significant neuroprotective effects, ameliorating learning and memory impairments in the Alzheimer's disease rat model. The treatment regimen modulated the activity of the BDNF/TRKB/CREB and GSK-3β/Tau pathways by influencing the expression of relevant genes, thereby reducing the generation of Aβ

Indexed as

Alzheimer's diseaseAmyloid-βEvodia rutaecarpaP-TauSchisandra chinensis

Identifiers

PMID38034776
PMCPMC10682611
OpenAlexW4388461439

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.