ArticleHeliyon2023
Detection of SARS-CoV-2 S protein based on FRET between carbon quantum dots and gold nanoparticles.
Article in Heliyon, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The trial behind it
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Who cites it
5 citing papers in PubMed.
- Trends of nucleic acid - based point-of-care diagnostics for infectious diseases.Journal of biological engineering · 2026Review
- Advances in Carbon Dot-Based Optical (Bio)Sensors for Contaminant Detection in Wastewater-Based Epidemiology.Sensors (Basel, Switzerland) · 2026Review
- A Sensitive Multichannel Fluorescent Polymer Sensor Array for the Detection of Protein Fluctuations in Serum.Sensors (Basel, Switzerland) · 2026Article
- Advanced fluorescence biosensor utilizing nitrogen/oxygen-doped carbon quantum dots in a modified carboxy cellulose matrix for quantitative detection of SARS-CoV-2 spike protein.Discover nano · 2026Article
- Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The COVID-19 pandemic caused by SARS-CoV-2 virus brings nasty crisis for public health in the world. Until now, the virus has caused multiple infections in many people. Detecting antigen to SARS-CoV-2 is a powerful method for the diagnosis of COVID-19 and is helpful for controlling and stopping the pandemic. Herein, a rapid and quantitative detection method of SARS-CoV-2 spike(S) protein was built based on the fluorescence resonance energy transfer (FRET) phenomenon without complicated steps. In the process of detecting, the carbon quantum dots (CQDs) and gold nanoparticles (AuNPs) act as donor and acceptor. By modifying the SARS-CoV-2 antibodies on the surface of CQDs and AuNPs, we achieved S protein specific detection using the distance-based FRET phenomenon. Through the electric charge regulation, the limit of detection (LOD) is 0.05 ng/mL, the linear range is 0.1-100 ng/mL, and the detection process only takes 12 min. The proposed method exhibits several advantages such as be available for variants (B.1.1.529 and B.1.617.2) and be suitable for human serum, which is of significance for detecting viral in time and prevention the viral transmission.
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Registered trials
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