Evidence map›Paper›PMID 38034565›Full record

ArticleFrontiers in plant science2023

SARS-CoV-2 spike protein S1 subunit induces potent neutralizing responses in mice and is effective against Delta and Omicron variants.

Tarlan Mamedov, Damla Yuksel, Irem Gurbuzaslan, Burcu Gulec, Gulshan Mammadova, Aykut Ozdarendeli, Shaikh Terkis Islam Pavel, Hazel Yetiskin, Busra Kaplan, Muhammet Ali Uygut and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in plant science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Tarlan MamedovDepartment of Agricultural Biotechnology, Akdeniz University, Antalya, Türkiye.
Damla YukselDepartment of Agricultural Biotechnology, Akdeniz University, Antalya, Türkiye.
Irem GurbuzaslanDepartment of Agricultural Biotechnology, Akdeniz University, Antalya, Türkiye.
Burcu GulecDepartment of Agricultural Biotechnology, Akdeniz University, Antalya, Türkiye.
Gulshan MammadovaDepartment of Agricultural Biotechnology, Akdeniz University, Antalya, Türkiye.
Aykut OzdarendeliDepartment of Microbiology, Medical Faculty, Erciyes University, Kayseri, Türkiye.
Shaikh Terkis Islam PavelDepartment of Microbiology, Medical Faculty, Erciyes University, Kayseri, Türkiye.
Hazel YetiskinDepartment of Microbiology, Medical Faculty, Erciyes University, Kayseri, Türkiye.
Busra KaplanDepartment of Microbiology, Medical Faculty, Erciyes University, Kayseri, Türkiye.
Muhammet Ali UygutDepartment of Microbiology, Medical Faculty, Erciyes University, Kayseri, Türkiye.
Gulnara HasanovaDepartment of Agricultural Biotechnology, Akdeniz University, Antalya, Türkiye.
Akdeniz University · TRErciyes University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

SARS-CoV-2, the virus responsible for the COVID-19 pandemic, belongs to the betacoronavirus genus. This virus has a high mutation rate, which rapidly evolves into new variants with different properties, such as increased transmissibility or immune evasion. Currently, the most prevalent global SARS-CoV-2 variant is Omicron, which is more transmissible than previous variants. Current available vaccines may be less effective against some currently existing SARS-CoV-2 variants, including the Omicron variant. The S1 subunit of the spike protein of SARS-CoV-2 has been a major target for COVID-19 vaccine development. It plays a crucial role in the virus's entry into host cells and is the primary target for neutralizing antibodies. In this study, the S1 subunit of the spike protein of SARS-CoV-2 was engineered and produced at a high level in

Indexed as

deltaOmicron variantsplant transient expression systemS1 subunits of spike proteinSARS-CoV-2

Identifiers

PMID38034565
PMCPMC10682712
OpenAlexW4388661822

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.