Evidence map›Paper›PMID 38034362›Full record

ArticleiScience2023

A common single nucleotide polymorphism is associated with inflammation and critical illness outcomes.

Fayten El-Dehaibi, Ruben Zamora, Josiah Radder, Jinling Yin, Ashti M Shah, Rami A Namas, Michelle Situ, Yanwu Zhao, William Bain, Alison Morris and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 1 institution in 1 country.

Fayten El-DehaibiDepartment of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Ruben ZamoraDepartment of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Josiah RadderDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Jinling YinDepartment of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Ashti M ShahPhysician Scientist Training Program, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Rami A NamasDepartment of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Michelle SituDepartment of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Yanwu ZhaoDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
William BainDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Alison MorrisDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Bryan J McVerryDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Derek A BarclayDepartment of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Timothy R BilliarDepartment of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Yingze ZhangDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Georgios D KitsiosDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Yoram VodovotzDepartment of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA.
University of Pittsburgh · US

Funding

Regulation of Cardiolin Byosynthesis in Epithelial InjuryP01HL114453 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MALLAMPALLI, RAMA K · 2014 to 2023
$21.3M
Translational Training Program in Pulmonary Biology and MedicineT32HL007563 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Melanie Koenigshoff · 1985 to 2026
$12.3M
Mechanisms of Immune Dysfunction after Trauma and Surgical SepsisR35GM127027 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TIMOTHY R BILLIAR · 2018 to 2026
$5.7M
Microbial Determinants of Acute Respiratory Distress Syndrome Severity (MiDAS)R03HL162655 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KITSIOS, GEORGIOS · 2022 to 2023
$159k
Platelet factors attenuate alveolar injury during severe pneumoniaIK2BX004886 · VA · VETERANS HEALTH ADMINISTRATION · PI BAIN, WILLIAM G · 2020 to 2024
–
BLRD VA IK2 BX004886NHLBI NIH HHS P01 HL114453NHLBI NIH HHS R03 HL162655NHLBI NIH HHS T32 HL007563NIGMS NIH HHS R35 GM127027
6 · The paper itself

Abstract

Acute inflammation is heterogeneous in critical illness and predictive of outcome. We hypothesized that genetic variability in novel, yet common, gene variants contributes to this heterogeneity and could stratify patient outcomes. We searched algorithmically for significant differences in systemic inflammatory mediators associated with any of 551,839 SNPs in one derivation (n = 380 patients with blunt trauma) and two validation (n = 75 trauma and n = 537 non-trauma patients) cohorts. This analysis identified rs10404939 in the

Indexed as

Clinical geneticsHealth sciencesMedicine

Identifiers

PMID38034362
PMCPMC10684809
OpenAlexW4388189196

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.