Evidence map›Paper›PMID 38034359›Full record

ArticleiScience2023

Mof plays distinct roles in hepatic lipid metabolism under healthy or non-alcoholic fatty liver conditions.

Xinghong Guo, Kai Liang, Longqing Xia, Xu Zhang, Jinbo Liu, Chuan Wang, Jinquan Li, Xiangzhi Li, Xinguo Hou, Li Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Xinghong GuoDepartment of Endocrinology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China.
Kai LiangDepartment of Endocrinology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China.
Longqing XiaDepartment of Endocrinology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China.
Xu ZhangShandong Provincial Key Laboratory of Animal Cells and Developmental Biology, Life Science School of Shandong University, Qingdao, Shandong 266237, China.
Jinbo LiuDepartment of Endocrinology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China.
Chuan WangDepartment of Endocrinology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China.
Jinquan LiDepartment of Endocrinology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China.
Xiangzhi LiShandong Provincial Key Laboratory of Animal Cells and Developmental Biology, Life Science School of Shandong University, Qingdao, Shandong 266237, China.
Xinguo HouDepartment of Endocrinology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China.
Li ChenDepartment of Endocrinology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China.
Shandong University · CNQilu Hospital of Shandong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The disturbance of hepatic lipid metabolism has a strong association with non-alcoholic fatty liver disease (NAFLD) and diabetes. Mof, an acetyltransferase involved in obesity and carbon metabolism, has not been thoroughly examined in its connection to hepatic metabolism. We aimed to explore the impact of Mof on hepatic lipid metabolism. The alteration of Mof expression was found in both obese mice and NAFLD human liver. The genes regulated by Mof were closely associated with lipid metabolism. In normal mice or hepatic cells, the down-regulation or inhibition of Mof resulted in increased lipid accumulation due to decreased PPARα expression. Conversely, in diet-induced obesity (DIO) mice or hepatic cells treated with palmitic acid, the inhibition of Mof led to improved lipid metabolism, attributed to the reduction in

Indexed as

Cell biologyMolecular biologyPhysiology

Identifiers

PMID38034359
PMCPMC10687339
OpenAlexW4388673097

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.