ArticleJournal of oral and maxillofacial pathology : JOMFP
To evaluate the role of lactate dehydrogenase as biomarker in the progression of potentially malignant disorders in smokers and gutkha chewers.
Article in Journal of oral and maxillofacial pathology : JOMFP. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed, 1 citations in OpenAlex.
- Lactate metabolism and lactylation in cancer: from pathogenesis to therapeutic advances.Signal transduction and targeted therapy · 2026Review
- Factors influencing salivary lactate dehydrogenase levels in oral squamous cell carcinoma and oral potentially malignant disorders.Frontiers in oral health · 2024Article
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
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Abstract
Aim: To evaluate the role of lactate dehydrogenase (LDH) as a biomarker in the progression of potentially malignant disorders in smokers and gutkha chewers. Material and Methods: The total of 70 individuals having the habit of chewing gutkha and smoking were selected for the study and divided into four groups. Group 1: 20 individuals having the habit of smoking, Group 2: 20 individuals having the habit of chewing gutkha, Group 3: 20 individuals having the habit of smoking and gutkha chewing, and Group 4: 10 healthy individuals. Results: In the present study showed that unstimulated whole saliva from group 1, group 2, and group 3 individuals, there was a significant decrease in isoenzymes LDH-1 and LDH-2 and there was no effect on LDH-3 isoenzyme. In the present study, there is a significant increase in salivary isoenzyme LDH-4. The result indicated that there is an effect of carcinogen (tobacco)-enhanced activity on salivary LDH. The present study showed 70 volunteers reported a statistical significant correlation among the groups. The individuals with habit of smoking and gutkha chewing showed Conclusion: There was a significant correlation between the levels of salivary LDH isoenzymes and cytomorphometric analysis of oral epithelium in smokers and gutkha chewers.
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