Evidence map›Paper›PMID 38033949›Full record

ArticleJournal of oral and maxillofacial pathology : JOMFP

Differential expression of Cadherins switch and Caveolin-2 during stages of oral carcinogenesis.

Rebeca B Nascimento, Isadora A R Machado, Jamerson C Silva, Lorena A S Faria, Fernanda C Borba, Lia P A Porto, Jean N Santos, Luciana M P Ramalho, Camila O Rodini, Maria Fernanda S D Rodrigues and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of oral and maxillofacial pathology : JOMFP. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Rebeca B NascimentoPhD in Dentistry and Health, Department of Propaedeutics and Integrated Clinical, School of Dentistry, Federal University of Bahia, Salvador, Brazil.
Isadora A R MachadoPhD in Dentistry and Health, Department of Propaedeutics and Integrated Clinical, School of Dentistry, Federal University of Bahia, Salvador, Brazil.
Jamerson C SilvaPhD Student in Dentistry and Health Postgraduated Program, Department of Propaedeutics and Integrated Clinical, School of Dentistry, Federal University of Bahia, Recife, PE, Brazil.
Lorena A S FariaDDS, Department of Propaedeutics and Integrated Clinical, School of Dentistry, Federal University of Bahia, Salvador, Brazil.
Fernanda C BorbaDDS, Department of Propaedeutics and Integrated Clinical, School of Dentistry, Federal University of Bahia, Salvador, Brazil.
Lia P A PortoPhD in Dentistry, Health Sciences Center, School of Dentistry, Federal University of Pernambuco, Recife, PE, Brazil.
Jean N SantosPhD Professor, Surgical Pathology Laboratory, Department of Propaedeutics and Integrated Clinical, School of Dentistry, Federal University of Bahia, Salvador, BA, Brazil.
Luciana M P RamalhoPhD Professor, Surgical Pathology Laboratory, Department of Propaedeutics and Integrated Clinical, School of Dentistry, Federal University of Bahia, Salvador, BA, Brazil.
Camila O RodiniPhD Professor, Department of Biological Sciences, School of Dentistry, University of São Paulo, São Paulo, SP, Brazil.
Maria Fernanda S D RodriguesPhD Professor, Biophotonics Applied to Health Sciences Postgraduated Program, University of the Ninth of July, São Paulo, SP, Brazil.
Katiúcia B S PaivaPhD Professor, Extracellular Matrix Biology and Cellular Interaction Laboratory, Department of Anatomy, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP, Brazil.
Flávia C A XavierPhD Professor, Surgical Pathology Laboratory, Department of Propaedeutics and Integrated Clinical, School of Dentistry, Federal University of Bahia, Salvador, BA, Brazil.
Universidade Federal da Bahia · BRUniversidade de São Paulo · BRUniversidade Federal de Pernambuco · BRUniversidade Nove de Julho · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Oral squamous cell carcinoma (OSCC) accounts for 90% of oral malignancies, which may be preceded by oral potentially malignant disorders (OPMDs). Cancer progression involves the downregulation of epithelial markers (E-cadherin) and the upregulation of mesenchymal markers (N-cadherin), which together characterise the epithelial-mesenchymal transition (EMT). Furthermore, caveolin can act on cell adhesion and migration events that regulate the expression of the E-cadherin/α-β-catenin complex, thus favouring aggressive biological behaviour. This study aimed to analyse the immunoexpression of E-cadherin, N-cadherin and caveolin-2 at different stages of oral carcinogenesis to identify reliable biomarkers to predict malignant potential. Methods: Expressions of E-cadherin and N-cadherin in 14 normal oral mucosae (NOM), 14 OPMD and 33 OSCC specimens were evaluated using immunohistochemistry. Clinicopathological parameters were also assessed. Results: E-cadherin immunoexpression was significantly reduced during the progression of oral carcinogenesis ( Conclusion: These findings indicate that cadherin switch and caveolin-2 immunoexpression may be regulatory events in oral carcinogenesis.

Indexed as

Cadherinscaveolin-2immunohistochemistryoral squamous cell carcinoma

Identifiers

PMID38033949
PMCPMC10683880
OpenAlexW4389244435

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.