Evidence map›Paper›PMID 38033888›Full record

ArticleChemical science2023

On-capillary alkylation micro-reactor: a facile strategy for proteo-metabolome profiling in the same single cells.

Yingyun He, Huiming Yuan, Yu Liang, Xinxin Liu, Xiaozhe Zhang, Yahui Ji, Baofeng Zhao, Kaiguang Yang, Jue Zhang, Shen Zhang and 2 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

  1. Living single-cell metabolomicsChemical science · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Yingyun HeCAS Key Laboratory of Separation Science for Analytical Chemistry, National Chromatographic Research and Analysis Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences Dalian 116023 China huimingyuan@dicp.ac.cn lihuazhang@dicp.ac.cn.
Huiming YuanCAS Key Laboratory of Separation Science for Analytical Chemistry, National Chromatographic Research and Analysis Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences Dalian 116023 China huimingyuan@dicp.ac.cn lihuazhang@dicp.ac.cn.
Yu LiangCAS Key Laboratory of Separation Science for Analytical Chemistry, National Chromatographic Research and Analysis Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences Dalian 116023 China huimingyuan@dicp.ac.cn lihuazhang@dicp.ac.cn.
Xinxin LiuCAS Key Laboratory of Separation Science for Analytical Chemistry, National Chromatographic Research and Analysis Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences Dalian 116023 China huimingyuan@dicp.ac.cn lihuazhang@dicp.ac.cn.
Xiaozhe ZhangCAS Key Laboratory of Separation Science for Analytical Chemistry, National Chromatographic Research and Analysis Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences Dalian 116023 China huimingyuan@dicp.ac.cn lihuazhang@dicp.ac.cn.
Yahui JiCAS Key Laboratory of Separation Science for Analytical Chemistry, National Chromatographic Research and Analysis Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences Dalian 116023 China huimingyuan@dicp.ac.cn lihuazhang@dicp.ac.cn.
Baofeng ZhaoCAS Key Laboratory of Separation Science for Analytical Chemistry, National Chromatographic Research and Analysis Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences Dalian 116023 China huimingyuan@dicp.ac.cn lihuazhang@dicp.ac.cn.ORCID https://orcid.org/0000-0003-3540-8893
Kaiguang YangCAS Key Laboratory of Separation Science for Analytical Chemistry, National Chromatographic Research and Analysis Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences Dalian 116023 China huimingyuan@dicp.ac.cn lihuazhang@dicp.ac.cn.ORCID https://orcid.org/0000-0001-9544-2714
Jue ZhangClinical Research Center for Reproduction and Genetics in Hunan Province, Reproductive and Genetic Hospital of CITIC-XIANGYA Changsha 410013 China.
Shen ZhangClinical Research Center for Reproduction and Genetics in Hunan Province, Reproductive and Genetic Hospital of CITIC-XIANGYA Changsha 410013 China.
Yukui ZhangCAS Key Laboratory of Separation Science for Analytical Chemistry, National Chromatographic Research and Analysis Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences Dalian 116023 China huimingyuan@dicp.ac.cn lihuazhang@dicp.ac.cn.
Lihua ZhangCAS Key Laboratory of Separation Science for Analytical Chemistry, National Chromatographic Research and Analysis Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences Dalian 116023 China huimingyuan@dicp.ac.cn lihuazhang@dicp.ac.cn.ORCID https://orcid.org/0000-0003-2543-1547
Dalian Institute of Chemical Physics · CNReproductive & Genetic Hospital CITIC-Xiangya · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Single-cell multi-omics analysis can provide comprehensive insights to study cell-to-cell heterogeneity in normal and disease physiology. However, due to the lack of amplification technique, the measurement of proteome and metabolome in the same cell is challenging. Herein, a novel on-capillary alkylation micro-reactor (OCAM) was developed to achieve proteo-metabolome profiling in the same single cells, by which proteins were first covalently bound to an iodoacetic acid functionalized open-tubular capillary micro-reactor

Identifiers

PMID38033888
PMCPMC10686037
OpenAlexW4388659697

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.