Evidence map›Paper›PMID 38033748›Full record

ArticleSaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society2023

In vitro anti-inflammatory, antidiabetic, antibacterial, and in silico studies of Ferruginan A isolated from

Abdur Rauf, Bassam Oudh Aljohny, Umer Rashid, Yasir Anwar, Zafar Ali Shah, Naveed Muhammad, Anees Ahmed Khalil, Ahood Khalid, Gauhar Rehman

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Bioprospection ofInternational journal of medical sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Abdur RaufDepartment of Chemistry, University of Swabi, Swabi, Anbar, 23430 Khyber Pakhtunkhwa (KP), Pakistan.
Bassam Oudh AljohnyDepartment of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah 21441, Saudi Arabia.
Umer RashidDepartment of Chemistry, COMSATS University Islamabad, 22060 Abbottabad, Pakistan.
Yasir AnwarDepartment of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah 21441, Saudi Arabia.
Zafar Ali ShahDepartment of Chemistry, University of Swabi, Swabi, Anbar, 23430 Khyber Pakhtunkhwa (KP), Pakistan.
Naveed MuhammadDepartment of Pharmacy, Abdul Wali Khan University, Mardan 23200, Pakistan.
Anees Ahmed KhalilUniversity Institute of Diet and Nutritional Sciences, Faculty of Allied Health Sciences, The University of Lahore, Pakistan.
Ahood KhalidUniversity Institute of Diet and Nutritional Sciences, Faculty of Allied Health Sciences, The University of Lahore, Pakistan.
Gauhar RehmanDepartment of Zoology, Abdul Wali Khan University, Mardan 23200, Pakistan.
Abdul Wali Khan University Mardan · PKKing Abdulaziz University · SAUniversity of Lahore · PKUniversity of Swabi · PKCOMSATS University Islamabad · PK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Traditionally, Methods: Ferruginan A was isolated from the ethyl acetate extract of Results: Regarding the anti-inflammatory effect, the tested compound demonstrated a 69.82 % inhibition at a concentration of 100 µg/mL, while the Ferruginan A (100 µl/mL) increased the uptake of glucose (3.79-71.86 %) in the yeast cell. Similarly, the zone of inhibition values of Ferruginan A (24.98 mm) against Escherichia coli were found to be comparable to standard (Imipenem: 31.09 mm). The mechanism of antidiabetic and anti-inflammatory effects was explored by using docking simulations performed on four molecular targets related to diabetes and inflammation. The results showed that the isolated compound may act as an antidiabetic agent by inhibiting the 5' Adenosine monophosphate-activated protein kinase (AMPK). While it also showed inhibition of anti-inflammatory targets COX-1, COX-2, and Tumor necrosis factor alpha (TNF-α). The ADMET prediction study revealed that isolated compound possesses favorable ADMET profile. Conclusion: It was concluded that Ferruginan A might be a significant anti-inflammatory and antidiabetic molecule.

Indexed as

AntidiabeticAnti-inflammatoryIn-Silico studyOleaceaeOlea ferruginea

Identifiers

PMID38033748
PMCPMC10682662
OpenAlexW4388493831

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.