Evidence map›Paper›PMID 38033699›Full record

ArticleClinical case reports2023

Successful treatment with nivolumab in a patient with unresectable oral squamous cell carcinoma following ineffective chemoradiotherapy.

Katsuhisa Sekido, Shuichi Imaue, Hidetake Tachinami, Kei Tomihara, Norihito Naruto, Kentaro Yamagishi, Atsushi Ikeda, Kumiko Fujiwara, Makoto Noguchi

Open access · goldAbstract readCase Reports
In one paragraph

Article in Clinical case reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.4field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Microenvironment-based immunotherapy in oral cancer: a comprehensive review.Medical oncology (Northwood, London, England) · 2025
    Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Katsuhisa SekidoDepartment of Oral and Maxillofacial Surgery, Faculty of Medicine, Academic Assembly University of Toyama 2630 Sugitani Toyama City Japan.ORCID https://orcid.org/0000-0002-9858-5961
Shuichi ImaueDepartment of Oral and Maxillofacial Surgery, Faculty of Medicine, Academic Assembly University of Toyama 2630 Sugitani Toyama City Japan.
Hidetake TachinamiDepartment of Oral and Maxillofacial Surgery, Faculty of Medicine, Academic Assembly University of Toyama 2630 Sugitani Toyama City Japan.ORCID https://orcid.org/0000-0001-9255-6863
Kei TomiharaDivisions of Oral and Maxillofacial Surgery Niigata University Graduate School of Medical and Dental Sciences Niigata Japan.ORCID https://orcid.org/0000-0002-8147-6603
Norihito NarutoDepartment of Radiology, Faculty of Medicine, Academic Assembly University of Toyama Toyama City Japan.
Kentaro YamagishiDepartment of Radiology, Faculty of Medicine, Academic Assembly University of Toyama Toyama City Japan.
Atsushi IkedaDepartment of Oral and Maxillofacial Surgery, Faculty of Medicine, Academic Assembly University of Toyama 2630 Sugitani Toyama City Japan.
Kumiko FujiwaraDepartment of Dentistry and Oral Surgery, Division of Medicine for Function and Morphology of Sensory Organs, Faculty of Medicine Osaka Medical and Pharmaceutical University Takatsuki Japan.ORCID https://orcid.org/0000-0001-9158-4141
Makoto NoguchiDepartment of Oral and Maxillofacial Surgery, Faculty of Medicine, Academic Assembly University of Toyama 2630 Sugitani Toyama City Japan.
University of Toyama · JPNiigata University · JPOsaka University of Pharmaceutical Sciences · JPToyama City Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Key clinical message: Nivolumab has been clinically successful in prolonging the overall survival of patients with recurrent and metastatic head and neck cancer, complete remission is rare. Synergistic combinations of immunotherapy and conventional cancer treatments, such as radiotherapy or chemotherapy, are likely to be the most viable strategies for improving patient responses. Abstract: Immune checkpoint inhibitors have revolutionized recurrent, metastatic oral cancer treatment; however complete remission in advanced stages is unusual. We present a case of complete remission of advanced oral squamous cell carcinoma for >4 years in a 64-year-old Japanese woman, that responded poorly to chemoradiotherapy but well to subsequent nivolumab treatment.

Indexed as

chemoradiotherapycomplete remissionimmune checkpoint inhibitornivolumaboral squamous cell carcinoma

Identifiers

PMID38033699
PMCPMC10683031
OpenAlexW4389084165

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.