Evidence map›Paper›PMID 38033549›Full record

ArticleFrontiers in neuroscience2023

Pharmacokinetic differences in nicotine and nicotine salts mediate reinforcement-related behavior: an animal model study.

Pengfei Han, Xiaoyuan Jing, Shulei Han, Xinsheng Wang, Qiannan Li, Yuan Zhang, Pengpeng Yu, Xin-An Liu, Ping Wu, Huan Chen and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Mind, Mood and Microbiota-Gut-Brain Axis in Psychiatric Disorders.International journal of molecular sciences · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 1 country.

Pengfei HanInstitute of Biomedical Engineering, College of Life Sciences, Qingdao University, Qingdao, China.
Xiaoyuan JingShenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Shulei HanChina National Tobacco Quality Supervision and Test Center, Zhengzhou, China.
Xinsheng WangInstitute of Biomedical Engineering, College of Life Sciences, Qingdao University, Qingdao, China.
Qiannan LiChina National Tobacco Quality Supervision and Test Center, Zhengzhou, China.
Yuan ZhangChina National Tobacco Quality Supervision and Test Center, Zhengzhou, China.
Pengpeng YuChina National Tobacco Quality Supervision and Test Center, Zhengzhou, China.
Xin-An LiuShenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Ping WuNational Institute on Drug Dependence and Beijing Key Laboratory of Drug Dependence, Beijing, China.
Huan ChenChina National Tobacco Quality Supervision and Test Center, Zhengzhou, China.
Hongwei HouChina National Tobacco Quality Supervision and Test Center, Zhengzhou, China.
Qingyuan HuChina National Tobacco Quality Supervision and Test Center, Zhengzhou, China.
Beijing Academy of Science and Technology · CNQingdao University · CNTobacco Research Institute · CNChina Tobacco · CNChinese Academy of Sciences · CNNational Institutes for Food and Drug Control · CNShenzhen Institutes of Advanced Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Since their introduction in the United States and Europe in 2007, electronic cigarettes (E-Cigs) have become increasingly popular among smokers. Nicotine, a key component in both tobacco and e-cigarettes, can exist in two forms: nicotine-freebase (FBN) and nicotine salts (NS). While nicotine salt is becoming more popular in e-cigarettes, the effect of nicotine salts on reinforcement-related behaviors remains poorly understood. This study aimed to compare the reinforcing effects of nicotine and nicotine salts in animal models of drug self-administration and explore potential mechanisms that may contribute to these differences. The results demonstrated that three nicotine salts (nicotine benzoate, nicotine lactate, and nicotine tartrate) resulted in greater reinforcement-related behaviors in rats compared to nicotine-freebase. Moreover, withdrawal-induced anxiety symptoms were lower in the three nicotine salt groups than in the nicotine-freebase group. The study suggested that differences in the pharmacokinetics of nicotine-freebase and nicotine salts

Indexed as

anxietydopaminenicotine saltspharmacokineticsself-administration

Identifiers

PMID38033549
PMCPMC10687399
OpenAlexW4388747476

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.