ArticleBeilstein journal of organic chemistry2023
Active-metal template clipping synthesis of novel [2]rotaxanes.
Article in Beilstein journal of organic chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Inverted metal-free active template synthesis of rotaxanes via axle‑mediated macrocyclization.Nature chemistry · 2026Article
- Active Templating by Mechanochemistry.Organic letters · 2026Article
- Rotaxane synthesisRSC advances · 2025Article
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4 authors.
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Abstract
Mechanically interlocked molecules (MIMs) have been important synthetic targets in supramolecular chemistry due to their beautiful structures and intriguing properties. We present herein a new synthetic strategy to access [2]rotaxanes, namely active-metal template clipping. We discuss the design of the target [2]rotaxanes, synthesis and characterization of the axle, macrocycle precursors and macrocycles as well as preparation of the final [2]rotaxanes by active template copper(I)-catalyzed alkyne-azide cycloaddition (CuAAC) as key step of the synthesis. HRMS and NMR experiments have been performed to confirm the formation of the interlocked structures.
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