Evidence map›Paper›PMID 38033368›Full record

ArticleMaterials today. Bio2023

OpiCa1-PEG-PLGA nanomicelles antagonize acute heart failure induced by the cocktail of epinephrine and caffeine.

Jun Li, Fei Wang, Xinyan Liu, Zhixiao Yang, Xiaoyu Hua, Hongqiao Zhu, Carmen R Valdivia, Li Xiao, Songyu Gao, Héctor H Valdivia and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Single-Residue Substitution of Opicalcin1 Enhances Cellular Uptake but Reduces CaChembiochem : a European journal of chemical biology · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Jun LiCollege of Veterinary Medicine, Shanxi Agricultural University, ShanXi, TaiGu, 030801, China.
Fei WangDepartment of Occupational and Environmental Health, Faculty of Naval Medicine, Naval Medical University (Second Military Medical University), Shanghai, 200433, China.
Xinyan LiuDepartment of Traditional Chinese Medicine Surgery, The First Affiliated Hospital of the Navy Medical University (Changhai Hospital), Shanghai, 200433, China.
Zhixiao YangDepartment of Occupational and Environmental Health, Faculty of Naval Medicine, Naval Medical University (Second Military Medical University), Shanghai, 200433, China.
Xiaoyu HuaDepartment of Occupational and Environmental Health, Faculty of Naval Medicine, Naval Medical University (Second Military Medical University), Shanghai, 200433, China.
Hongqiao ZhuDepartment of Traditional Chinese Medicine Surgery, The First Affiliated Hospital of the Navy Medical University (Changhai Hospital), Shanghai, 200433, China.
Carmen R ValdiviaDepartment of Medicine and Cardiovascular Research Center, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA.
Li XiaoDepartment of Medicine and Cardiovascular Research Center, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA.
Songyu GaoDepartment of Occupational and Environmental Health, Faculty of Naval Medicine, Naval Medical University (Second Military Medical University), Shanghai, 200433, China.
Héctor H ValdiviaDepartment of Medicine and Cardiovascular Research Center, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA.
Liang XiaoDepartment of Occupational and Environmental Health, Faculty of Naval Medicine, Naval Medical University (Second Military Medical University), Shanghai, 200433, China.
Jinming WangCollege of Veterinary Medicine, Shanxi Agricultural University, ShanXi, TaiGu, 030801, China.
University of Wisconsin–Madison · USSecond Military Medical University · CNShanxi Agricultural University · CN

Funding

Ryanodine Receptors, Calcium-dependent Arrhythmias & HCMR01HL055438 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI VALDIVIA, HECTOR H · 1996 to 2023
$8.0M
Rational Design from Cryo-EM Structures of High-Affinity Ryanodine Receptor Ligands Based on Natural PeptidesR01HL170144 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI Hector H Valdivia · 2023 to 2026
$2.6M
NHLBI NIH HHS R01 HL055438NHLBI NIH HHS R01 HL170144
6 · The paper itself

Abstract

Background: Reducing Ca Methods: OpiCal-PEG-PLGA nanomicelles were prepared by thin film dispersion, of which the antagonistic effects were observed using an acute heart failure model induced by epinephrine and caffeine in mice. In addition, cardiac targeting, self-stability as well as biotoxicity were determined. Results: The synthesized OpiCa1-PEG-PLGA nanomicelles were elliptical with a particle size of 72.26 nm, a PDI value of 0.3, and a molecular weight of 10.39 kDa. The nanomicelles showed a significant antagonistic effect with 100 % survival rate to the death induced by epinephrine and caffeine, which was supported by echocardiography with significantly recovered heart rate, ejection fraction and left ventricular fractional shortening rate. The FITC labeled nanomicelles had a strong membrance penetrating capacity within 2 h and cardiac targeting within 12 h that was further confirmed by immunohistochemistry with a self-prepared OpiCa1 polyclonal antibody. Meanwhile, the nanomicelles can keep better stability and dispersibility Conclusion: Our study also provide a novel nanodelivery pathway for targeting RyRs and antagonizing the SR Ca

Indexed as

Acute heart failureCa2+OpiCa1-PEG-PLGA nanomicelleRyR2β-adrenergic stress

Identifiers

PMID38033368
PMCPMC10682124
OpenAlexW4388487475

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.