Evidence map›Paper›PMID 38033283›Full record

ArticleJournal of clinical oncology : official journal of the American Society of Clinical Oncology2024

Inflammatory Tongue Conditions and Risk of Oral Tongue Cancer Among the US Elderly Individuals.

Joseph E Tota, Eric A Engels, Mark W Lingen, Nishant Agrawal, Alexander R Kerr, Zachary S Zumsteg, Li C Cheung, Hormuzd A Katki, Christian C Abnet, Anil K Chaturvedi

Open access · greenAbstract read
In one paragraph

Article in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Effects of smoking cessation on taste function in heavy smokers undergoing hemiglossectomy for tongue squamous cell carcinoma.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025
    Article
  5. Article
  6. Advances in Photothermal Therapy for Oral Cancer.International journal of molecular sciences · 2025
    Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Joseph E TotaDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD.
Eric A EngelsDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD.ORCID 0000-0003-0203-6958
Mark W LingenUniversity of Chicago Pritzker School of Medicine, Chicago, IL.
Nishant AgrawalUniversity of Chicago Pritzker School of Medicine, Chicago, IL.
Alexander R KerrNew York University College of Dentistry, New York, NY.ORCID 0000-0002-2162-8572
Zachary S ZumstegCedars Sinai Medical Center, Los Angeles, CA.ORCID 0000-0001-7484-3631
Li C CheungDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD.ORCID 0000-0003-1625-4331
Hormuzd A KatkiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD.ORCID 0000-0003-2002-0095
Christian C AbnetDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD.ORCID 0000-0002-3008-7843
Anil K ChaturvediDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD.ORCID 0000-0003-2696-8899
National Cancer Institute · USUniversity of Chicago · USCedars-Sinai Medical Center · USMerck & Co., Inc., Rahway, NJ, USA (United States) · USNew York University · US

Funding

Studies of Head and Neck CancersZIACP010213 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI CHATURVEDI, ANIL · 2010 to 2025
$15.9M
NCI NIH HHS HHSN261201800009CNCI NIH HHS HHSN261201800009INCI NIH HHS HHSN261201800015CNCI NIH HHS HHSN261201800015INCI NIH HHS HHSN261201800032CNCI NIH HHS HHSN261201800032I
6 · The paper itself

Abstract

purposeThe incidence of oral tongue cancers has increased since the 1980s among US men and women for unknown reasons. We investigated associations of inflammatory tongue conditions with risk of cancers of the oral tongue, other oral cavity, and oropharynx among the US elderly individuals (age 65 years or older).

methodsWe conducted a case-control study (2,534 oral tongue cancers, 6,832 other oral cavity cancers, 9,373 oropharyngeal cancers, and 200,000 controls) within the SEER-Medicare data set (1992-2013). Medicare records were used to identify patients with clinically diagnosed inflammatory tongue conditions (glossitis, benign migratory glossitis, median rhomboid glossitis, atrophic glossitis, glossodynia, other specified conditions [eg, atrophy and hypertrophy], and other unspecified conditions) and oral precancer (leukoplakia/erythroplakia). Only conditions preceding cancer/control selection by >12 months were included.

resultsThe prevalence of inflammatory tongue conditions was significantly higher in patients with tongue cancer than controls (6.0%

conclusionInflammatory tongue conditions were associated with strongly increased risks of oral tongue cancers and preceded cancer diagnosis by several years, underscoring the need for increased clinical surveillance among patients with such apparently benign diagnoses.

Indexed as

Tongue NeoplasmsAgedAged, 80 and overCase-Control StudiesFemaleGlossitisGlossitis, Benign MigratoryHumansIncidenceMaleMedicarePrevalenceRisk FactorsSEER ProgramTongue DiseasesUnited States

Identifiers

PMID38033283
PMCPMC11095882
OpenAlexW4389163717

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.