Evidence map›Paper›PMID 38032548›Full record

ArticleThe Journal of organic chemistry2023

Electrifying Friedel-Crafts Intramolecular Alkylation toward 1,1-Disubstituted Tetrahydronaphthalenes.

Enrico Lunghi, Pietro Ronco, Federico Della Negra, Beatrice Trucchi, Massimo Verzini, Daniele Merli, Emanuele Casali, C Oliver Kappe, David Cantillo, Giuseppe Zanoni

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of organic chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Enrico LunghiDepartment of Chemistry, University of Pavia, Viale Taramelli, 27100 Pavia, Italy.
Pietro RoncoDepartment of Chemistry, University of Pavia, Viale Taramelli, 27100 Pavia, Italy.
Federico Della NegraFlamma S.p.A., Via Bedeschi, 24040 Chignolo D'isola, Italy.
Beatrice TrucchiFlamma S.p.A., Via Bedeschi, 24040 Chignolo D'isola, Italy.
Massimo VerziniFlamma S.p.A., Via Bedeschi, 24040 Chignolo D'isola, Italy.
Daniele MerliDepartment of Chemistry, University of Pavia, Viale Taramelli, 27100 Pavia, Italy.ORCID 0000-0003-3975-0127
Emanuele CasaliDepartment of Chemistry, University of Pavia, Viale Taramelli, 27100 Pavia, Italy.ORCID 0000-0001-7501-5213
C Oliver KappeInstitute of Chemistry, University of Graz, NAWI Graz, Graz 8010, Austria.ORCID 0000-0003-2983-6007
David CantilloInstitute of Chemistry, University of Graz, NAWI Graz, Graz 8010, Austria.ORCID 0000-0001-7604-8711
Giuseppe ZanoniDepartment of Chemistry, University of Pavia, Viale Taramelli, 27100 Pavia, Italy.ORCID 0000-0003-1530-9409
University of Pavia · ITUniversity of Graz · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this work, we successfully employed electrochemical conditions to promote a Hofer-Moest, intramolecular Friedel-Crafts alkylation sequence. The reaction proceeds under mild conditions, employing carboxylic acids as starting materials. Notably, the electrochemical process performed in batch was adapted to a continuous flow electrolysis apparatus to provide a significant improvement. This catalyst-free, electrochemical approach produces an array of tetrahydronaphthalenes that could be used for API synthesis.

Identifiers

PMID38032548
PMCPMC10729024
OpenAlexW4389180711

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.