Evidence map›Paper›PMID 38032125›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024

Motile Living Biobots Self-Construct from Adult Human Somatic Progenitor Seed Cells.

Gizem Gumuskaya, Pranjal Srivastava, Ben G Cooper, Hannah Lesser, Ben Semegran, Simon Garnier, Michael Levin

Open access · goldAbstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 45 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. The Morphological, Behavioral, and Transcriptomic Life Cycle of Anthrobots.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  5. Article
  6. Article
  7. The Multiscale Wisdom of the Body: Collective Intelligence as a Tractable Interface for Next-Generation Biomedicine.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025
    Review
  8. Article
  9. Review
  10. Open problems in synthetic multicellularity.NPJ systems biology and applications · 2024
    Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Motile Living Biobots Self-Construct from Adult Human Somatic Progenitor Seed Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  17. Review
  18. Review
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Gizem GumuskayaAllen Discovery Center at Tufts University, and Department of Biology, Tufts University, Medford, MA, 02155, USA.ORCID 0000-0002-4691-0443
Pranjal SrivastavaAllen Discovery Center at Tufts University, and Department of Biology, Tufts University, Medford, MA, 02155, USA.
Ben G CooperAllen Discovery Center at Tufts University, and Department of Biology, Tufts University, Medford, MA, 02155, USA.
Hannah LesserAllen Discovery Center at Tufts University, and Department of Biology, Tufts University, Medford, MA, 02155, USA.
Ben SemegranAllen Discovery Center at Tufts University, and Department of Biology, Tufts University, Medford, MA, 02155, USA.
Simon GarnierFederated Department of Biological Sciences, New Jersey Institute of Technology, Newark, NJ, 07102, USA.
Michael LevinAllen Discovery Center at Tufts University, and Department of Biology, Tufts University, Medford, MA, 02155, USA.ORCID 0000-0001-7292-8084
Tufts University · USNew Jersey Institute of Technology · US

Funding

Acquisition of Leica confocal/multiphoton microscopeS10OD021624 · OD · TUFTS UNIVERSITY MEDFORD · PI GEORGAKOUDI, IRENE · 2016 to 2016
$600k
NIH HHS S10 OD021624
6 · The paper itself

Abstract

Fundamental knowledge gaps exist about the plasticity of cells from adult soma and the potential diversity of body shape and behavior in living constructs derived from genetically wild-type cells. Here anthrobots are introduced, a spheroid-shaped multicellular biological robot (biobot) platform with diameters ranging from 30 to 500 microns and cilia-powered locomotive abilities. Each Anthrobot begins as a single cell, derived from the adult human lung, and self-constructs into a multicellular motile biobot after being cultured in extra cellular matrix for 2 weeks and transferred into a minimally viscous habitat. Anthrobots exhibit diverse behaviors with motility patterns ranging from tight loops to straight lines and speeds ranging from 5-50 microns s

Indexed as

Extracellular MatrixNervous SystemCells, CulturedCiliaHumansMorphogenesisbiobotbioengineeringemergencemorphogenesisrepairself-assembly

Identifiers

PMID38032125
PMCPMC10811512
OpenAlexW4389178904

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.